Gene

ubr4

ID

ZDB-GENE-090313-341

Name

ubiquitin protein ligase E3 component n-recognin 4

Symbol

ubr4 Nomenclature History

Previous Names

si:dkey-7c22.2

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have ubiquitin-protein transferase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to localize to centrosome; cytosol; and nucleoplasm. Orthologous to human UBR4 (ubiquitin protein ligase E3 component n-recognin 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Tilghman et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ubr4 Human Ortholog

No data available

Associated With ubr4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003126	Zinc finger, UBR-type
Domain	IPR025704	E3 ubiquitin ligase UBR4, C-terminal
Domain	IPR045841	E3 ubiquitin-protein ligase UBR4, N-terminal
Domain	IPR047509	E3 ubiquitin-protein ligase UBR4-like, UBR-box
Family	IPR045189	E3 ubiquitin ligase UBR4-like
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily

Domain Details Per Protein

Protein	Length	Armadillo-type fold	E3 ubiquitin ligase UBR4, C-terminal	E3 ubiquitin ligase UBR4-like	E3 ubiquitin-protein ligase UBR4-like, UBR-box	E3 ubiquitin-protein ligase UBR4, N-terminal	WD40-repeat-containing domain superfamily	Zinc finger, UBR-type
UniProtKB:A0A8M6Z3V7 InterPro	5190
UniProtKB:A0A8M6YVC3 InterPro	5192
UniProtKB:A0A8M9PWV7 InterPro	5184
UniProtKB:A0A8M9PWV4 InterPro	5192
UniProtKB:A0A8M6YVZ4 InterPro	5187
UniProtKB:A0A8M9PQN9 InterPro	5144
UniProtKB:A0A8M9Q7V9 InterPro	5192
UniProtKB:A0A8M3AVE1 InterPro	5161
UniProtKB:A0A8M9PDY5 InterPro	5197
UniProtKB:A0A8M6YXU8 InterPro	5196
UniProtKB:A0A8M6Z3V2 InterPro	5197
UniProtKB:A0A8M6YVC7 InterPro	5181
UniProtKB:A0A8M6YVB9 InterPro	5198
UniProtKB:A0A8M6Z4I7 InterPro	5183

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ubr4-201 (1) Ensembl	Ensembl	15,869 nt	Select Tool
mRNA	ubr4-204 (1) Ensembl	Ensembl	15,519 nt	Select Tool ZFIN BLAST
ncRNA	ubr4-002 (1) Ensembl	Ensembl	939 nt	Select Tool
ncRNA	ubr4-003 (1) Ensembl	Ensembl	766 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations