Gene
eif4g3b
- ID
- ZDB-GENE-090312-49
- Name
- eukaryotic translation initiation factor 4 gamma, 3b
- Symbol
- eif4g3b Nomenclature History
- Previous Names
-
- eif4g3
- si:dkey-1a7.2
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable mRNA binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within regulation of translation and translation. Predicted to be part of eukaryotic translation initiation factor 4F complex. Orthologous to human EIF4G3 (eukaryotic translation initiation factor 4 gamma 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028503Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa13948 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15649 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18232 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24317 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| uab475 | Allele with one deletion | Unknown | Unknown | CRISPR |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-type fold | Initiation factor eIF-4 gamma, MA3 | MIF4G-like, type 3 | W2 domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PFF4 | InterPro | 1733 | ||||
| UniProtKB:A0A8M9P5G6 | InterPro | 1715 | ||||
| UniProtKB:A0A8M9PT74 | InterPro | 1726 | ||||
| UniProtKB:A0A8M9Q5C3 | InterPro | 1715 | ||||
| UniProtKB:A0A8M9Q5C1 | InterPro | 1733 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
eif4g3b-201
(1)
|
Ensembl | 5,031 nt | ||
| mRNA |
eif4g3b-203
(1)
|
Ensembl | 5,815 nt | ||
| ncRNA |
eif4g3b-002
(1)
|
Ensembl | 473 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-1A7 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-68L7 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068219396 (1) | 6016 nt | ||
| Genomic | GenBank:BX005235 (1) | 211618 nt | ||
| Polypeptide | UniProtKB:A0A8M9PFF4 (1) | 1733 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Le Faou, P., Völkel, P., and Angrand, P.O. (2011) The zebrafish genes encoding the Polycomb Repressive Complex (PRC) 1. Gene. 475(1):10-21
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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