Gene
ogdhb
- ID
- ZDB-GENE-090311-8
- Name
- oxoglutarate dehydrogenase b
- Symbol
- ogdhb Nomenclature History
- Previous Names
-
- si:ch211-229p19.3
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity. Acts upstream of or within heart contraction. Predicted to be located in nucleus. Predicted to be part of oxoglutarate dehydrogenase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in oxoglutarate dehydrogenase deficiency. Orthologous to human OGDH (oxoglutarate dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027200Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mn0281Gt | Transgenic insertion | Unknown | Frameshift | DNA | |
| sa11227 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34993 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ogdhb | Lin et al., 2023 | |
| CRISPR2-ogdhb | Lin et al., 2023 | |
| CRISPR3-ogdhb | LaCoursiere et al., 2024 | |
| CRISPR4-ogdhb | LaCoursiere et al., 2024 | |
| MO1-ogdhb | N/A | Keßler et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| oxoglutarate dehydrogenase deficiency | Alliance | Oxoglutarate dehydrogenase deficiency | 203740 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001017 | Dehydrogenase, E1 component |
| Domain | IPR005475 | Transketolase-like, pyrimidine-binding domain |
| Domain | IPR031717 | 2-oxoglutarate dehydrogenase E1 component/KDG, C-terminal |
| Domain | IPR032106 | 2-oxoglutarate dehydrogenase E1 component, N-terminal domain |
| Family | IPR011603 | 2-oxoglutarate dehydrogenase E1 component |
| Homologous_superfamily | IPR029061 | Thiamin diphosphate-binding fold |
| Homologous_superfamily | IPR042179 | Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | 2-oxoglutarate dehydrogenase E1 component | 2-oxoglutarate dehydrogenase E1 component/KDG, C-terminal | 2-oxoglutarate dehydrogenase E1 component, N-terminal domain | Dehydrogenase, E1 component | Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily | Thiamin diphosphate-binding fold | Transketolase-like, pyrimidine-binding domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7EZ05 | InterPro | 1023 | |||||||
| UniProtKB:A0A8M9PUH2 | InterPro | 1020 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-229P19 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-259K14 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001338145 (1) | 3493 nt | ||
| Genomic | GenBank:CT956056 (1) | 151889 nt | ||
| Polypeptide | UniProtKB:E7EZ05 (1) | 1023 aa |
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Lin, S.J., Vona, B., Lau, T., Huang, K., Zaki, M.S., Aldeen, H.S., Karimiani, E.G., Rocca, C., Noureldeen, M.M., Saad, A.K., Petree, C., Bartolomaeus, T., Abou Jamra, R., Zifarelli, G., Gotkhindikar, A., Wentzensen, I.M., Liao, M., Cork, E.E., Varshney, P., Hashemi, N., Mohammadi, M.H., Rad, A., Neira, J., Toosi, M.B., Knopp, C., Kurth, I., Challman, T.D., Smith, R., Abdalla, A., Haaf, T., Suri, M., Joshi, M., Chung, W.K., Moreno-De-Luca, A., Houlden, H., Maroofian, R., Varshney, G.K. (2023) Evaluating the association of biallelic OGDHL variants with significant phenotypic heterogeneity. Genome Medicine. 15:102102
- Sabharwal, A., Campbell, J.M., Schwab, T.L., WareJoncas, Z., Wishman, M.D., Ata, H., Liu, W., Ichino, N., Hunter, D.E., Bergren, J.D., Urban, M.D., Urban, R.M., Holmberg, S.R., Kar, B., Cook, A., Ding, Y., Xu, X., Clark, K.J., Ekker, S.C. (2022) A Primer Genetic Toolkit for Exploring Mitochondrial Biology and Disease Using Zebrafish. Genes. 13(8):
- Yang, Y., Dong, F., Liu, X., Xu, J., Wu, X., Zheng, Y. (2020) Thifluzamide induces the toxic effects on zebrafish (Danio rerio) via inhibition of succinate dehydrogenase (SDH). Environmental pollution (Barking, Essex : 1987). 265:115031
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Ma, Z., Zhu, P., Pang, M., Guo, L., Chang, N., Zheng, J., Zhu, X., Gao, C., Huang, H., Cui, Z., Xiong, J.W., Peng, J., Chen, J. (2017) A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants. Scientific Reports. 7:10381
- Keßler, M., Berger, I.M., Just, S., Rottbauer, W. (2015) Loss of dihydrolipoyl succinyltransferase (DLST) leads to reduced resting heart rate in the zebrafish. Basic Research in Cardiology. 110:468
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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