Gene
hecw2a
- ID
- ZDB-GENE-090311-22
- Name
- HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a
- Symbol
- hecw2a Nomenclature History
- Previous Names
-
- hecw2
- nedl2a (1)
- si:dkey-191g15.6
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of sodium ion transmembrane transporter activity; and regulation of dendrite morphogenesis. Predicted to localize to cytoplasm. Orthologous to human HECW2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Lu et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with hypotonia, seizures, and absent language | 617268 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000008 | C2 domain |
| Domain | IPR000569 | HECT domain |
| Domain | IPR001202 | WW domain |
| Domain | IPR032348 | E3 ubiquitin-protein ligase HECW1/2, N-terminal |
| Domain | IPR037795 | E3 ubiquitin-protein ligase HECW, C2 domain |
| Domain | IPR040524 | E3 ubiquitin-protein ligase HECW1, helical box domain |
| Family | IPR050409 | E3 ubiquitin-protein ligase |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR035983 | HECT, E3 ligase catalytic domain |
| Homologous_superfamily | IPR036020 | WW domain superfamily |
Domain Details Per Protein
| Protein | Length | C2 domain | C2 domain superfamily | E3 ubiquitin-protein ligase | E3 ubiquitin-protein ligase HECW1/2, N-terminal | E3 ubiquitin-protein ligase HECW1, helical box domain | E3 ubiquitin-protein ligase HECW, C2 domain | HECT domain | HECT, E3 ligase catalytic domain | WW domain | WW domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AW15
|
1475 | ||||||||||
|
UniProtKB:A0A8M3B5N0
|
1466 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hecw2a-201
(1)
|
Ensembl | 4,236 nt | ||
| mRNA |
hecw2a-202
(1)
|
Ensembl | 9,786 nt | ||
| mRNA |
hecw2a-203
(1)
|
Ensembl | 9,885 nt |
Interactions and Pathways
No data available
Plasmids
No data available