med16

ID

ZDB-GENE-090306-4

Name

mediator complex subunit 16

Symbol

med16 Nomenclature History

Previous Names

fc22c09
fc29h12
lppr3b
wu:fc22c09
wu:fc29h12

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription initiation by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of mediator complex. Orthologous to human MED16 (mediator complex subunit 16).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7136982 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Guillouet et al., 2025
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With med16 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Guillouet-Gordon syndrome	621220

Associated With med16 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR021665	Mediator complex, subunit Med16, N-terminal
Domain	IPR048339	Mediator complex subunit 16, C-terminal
Domain	IPR048616	Mediator of RNA polymerase II transcription subunit 16 , central helical bridge
Family	IPR048338	Mediator complex, subunit Med16
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat