Gene
nectin1b
- ID
- ZDB-GENE-090224-2
- Name
- nectin cell adhesion molecule 1b
- Symbol
- nectin1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have cell adhesion molecule binding activity; protein homodimerization activity; and signaling receptor activity. Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to localize to adherens junction. Human ortholog(s) of this gene implicated in cleft lip; cleft lip-palate-ectodermal dysplasia syndrome; cleft palate; and ectodermal dysplasia. Is expressed in nervous system. Orthologous to human NECTIN1 (nectin cell adhesion molecule 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cleft lip-palate-ectodermal dysplasia syndrome | Alliance | Cleft lip/palate-ectodermal dysplasia syndrome | 225060 |
| cleft lip-palate-ectodermal dysplasia syndrome | Alliance | Orofacial cleft 7 | 225060 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013106 | Immunoglobulin V-set domain |
| Domain | IPR013162 | CD80-like, immunoglobulin C2-set |
| Family | IPR051427 | Nectin and Nectin-like |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Length | CD80-like, immunoglobulin C2-set | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Immunoglobulin V-set domain | Nectin and Nectin-like |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B0JYH6
|
541 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nectin1b-201
(1)
|
Ensembl | 1,620 nt | ||
| mRNA |
nectin1b-202
(1)
|
Ensembl | 1,226 nt | ||
| ncRNA |
pvrl1b-002
(1)
|
Ensembl | 641 nt |
Interactions and Pathways
No data available
Plasmids
No data available