Gene
nectin1b
- ID
- ZDB-GENE-090224-2
- Name
- nectin cell adhesion molecule 1b
- Symbol
- nectin1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable cell adhesion molecule binding activity and protein homodimerization activity. Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and protein localization to cell junction. Predicted to act upstream of or within cell adhesion; regulation of synapse assembly; and virion attachment to host cell. Predicted to be located in cell-cell junction; membrane; and synapse. Predicted to be active in adherens junction. Is expressed in nervous system and palatoquadrate cartilage. Human ortholog(s) of this gene implicated in cleft lip; cleft lip-palate-ectodermal dysplasia syndrome; cleft palate; and ectodermal dysplasia. Orthologous to human NECTIN1 (nectin cell adhesion molecule 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cleft lip-palate-ectodermal dysplasia syndrome | Alliance | Cleft lip/palate-ectodermal dysplasia syndrome | 225060 |
| cleft lip-palate-ectodermal dysplasia syndrome | Alliance | Orofacial cleft 7 | 225060 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013106 | Immunoglobulin V-set domain |
| Domain | IPR013162 | CD80-like, immunoglobulin C2-set |
| Family | IPR051427 | Nectin and Nectin-like |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Length | CD80-like, immunoglobulin C2-set | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Immunoglobulin V-set domain | Nectin and Nectin-like |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B0JYH6
|
541 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nectin1b-201
(1)
|
Ensembl | 1,620 nt | ||
| mRNA |
nectin1b-202
(1)
|
Ensembl | 1,226 nt | ||
| ncRNA |
pvrl1b-002
(1)
|
Ensembl | 641 nt |
Interactions and Pathways
No data available
Plasmids
No data available