Gene

dync1i2b

ID

ZDB-GENE-090121-1

Name

dynein, cytoplasmic 1, intermediate chain 2b

Symbol

dync1i2b Nomenclature History

Previous Names

fk28d02
wu:fk28d02

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to contribute to ATP-dependent microtubule motor activity, plus-end-directed. Predicted to be involved in positive regulation of ATP-dependent microtubule motor activity, plus-end-directed and transport along microtubule. Predicted to localize to cytoplasmic dynein complex. Is expressed in female organism. Orthologous to human DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Newman et al., 2019

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dync1i2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with microcephaly and structural brain anomalies	618492

Associated With dync1i2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR025956	Cytoplasmic dynein 1 intermediate chain 1/2
Family	IPR050687	Dynein Intermediate Chain
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	Cytoplasmic dynein 1 intermediate chain 1/2	Dynein Intermediate Chain	WD40 repeat	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A0R4IXD8 InterPro	628
UniProtKB:A0A8M3B334 InterPro	645
UniProtKB:A0A8M3AT17 InterPro	625
UniProtKB:A0A8M3BA49 InterPro	608

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	dync1i2b-201 (1) Ensembl	Ensembl		1,887 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations