Gene

tjap1

ID

ZDB-GENE-081107-47

Name

tight junction associated protein 1 (peripheral)

Symbol

tjap1 Nomenclature History

Previous Names

sb:eu465
si:dkey-109m21.1

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to be involved in Golgi organization. Predicted to be located in membrane. Predicted to be active in trans-Golgi network. Is expressed in several structures, including axis; intestinal bulb; nervous system; notochord; and polster. Orthologous to human TJAP1 (tight junction associated protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from Thisse et al., 2005

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu465 (24 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa5856	Allele with one point mutation	Unknown	Premature Stop	ENU

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Sequence Targeting Reagents

No data available

Human Disease

Associated With tjap1 Human Ortholog

No data available

Associated With tjap1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR043470	Tight junction-associated protein 1 domain
Family	IPR043441	Junction-associated protein Tjap1/BEGAIN

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Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9QNZ6	InterPro	1099
UniProtKB:A0AB13A9T8	InterPro	677
UniProtKB:A0AB32T6J0	InterPro	687
UniProtKB:A0AB32T865	InterPro	975

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 13

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	tjap1-201 (1) Ensembl	Ensembl		5,536 nt	Select Tool ZFIN BLAST
mRNA	tjap1-202 (1) Ensembl	Ensembl		2,580 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-117C8	BX510320	ZFIN Curated Data
Contained in	BAC	DKEY-109M21	CT029995	ZFIN Curated Data
Encodes	EST	eu465	DU644705	Thisse et al., 2005

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001365539 (1)	5814 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX510320 (1)	170783 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A8M9QNZ6 (1)	1099 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	TJAP1	6	Ensembl:ENSG00000137221 Gene:93643 HGNC:17949 OMIM:612658	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Tjap1	17	Ensembl:ENSMUSG00000012296 Gene:74094 MGI:1921344	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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