Gene
wdr11
- ID
- ZDB-GENE-081107-28
- Name
- WD repeat domain 11
- Symbol
- wdr11 Nomenclature History
- Previous Names
-
- si:ch211-233m11.6
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Acts upstream of or within cilium assembly and neural crest cell migration. Located in axoneme. Is expressed in olfactory bulb. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder and hypogonadotropic hypogonadism 14 with or without anosmia. Orthologous to human WDR11 (WD repeat domain 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Kim et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Kim et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la012327Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027410Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa15911 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35403 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-wdr11 | N/A | Kim et al., 2017 |
| MO2-wdr11 | N/A | Kim et al., 2017 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 14 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 14 with or without anosmia | 614858 |
| Intellectual developmental disorder, autosomal recessive 78 | 620237 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily | WD repeat-containing protein 11 |
|---|---|---|---|---|---|---|
| UniProtKB:F1QEB7 | InterPro | 1239 | ||||
| UniProtKB:A0AB13ABR0 | InterPro | 1239 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-233M11 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-173P11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423963 (1) | |||
| Genomic | GenBank:CU372927 (1) | 191329 nt | ||
| Polypeptide | UniProtKB:A0AB13ABR0 (1) | 1239 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Kim, Y.J., Osborn, D.P., Lee, J.Y., Araki, M., Araki, K., Mohun, T., Känsäkoski, J., Brandstack, N., Kim, H.T., Miralles, F., Kim, C.H., Brown, N.A., Kim, H.G., Martinez-Barbera, J.P., Ataliotis, P., Raivio, T., Layman, L.C., Kim, S.H. (2017) WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome. EMBO reports. 19(2):269-289
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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