Gene

brip1

ID
ZDB-GENE-081107-11
Name
BRCA1 interacting helicase 1
Symbol
brip1 Nomenclature History
Previous Names
  • fancj (1)
  • Fanconi anemia, complementation group J
  • si:ch211-158l18.1
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to enable DNA helicase activity. Predicted to be involved in double-strand break repair involved in meiotic recombination and nucleotide-excision repair. Predicted to act upstream of or within nucleobase-containing compound metabolic process. Predicted to be active in nucleus. Is expressed in central nervous system; lens; oral epithelium; and pectoral fin fold. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group J; breast cancer; colorectal cancer; and thrombocytopenia. Orthologous to human BRIP1 (BRCA1 interacting DNA helicase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from Titus et al., 2009
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Ramanagoudr-Bhojappa et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With brip1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
breast cancer Alliance {Breast cancer, early-onset, susceptibility to} 114480
Fanconi anemia complementation group J Alliance Fanconi anemia, complementation group J 609054
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Associated With brip1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006554 Helicase-like, DEXD box c2 type
Domain IPR006555 ATP-dependent helicase, C-terminal
Domain IPR010614 RAD3-like helicase, DEAD
Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
Domain IPR014013 Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type
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Domain Details Per Protein
Protein Additional Resources Length ATP-dependent helicase, C-terminal ATP-dependent helicase Rad3/Chl1-like Helicase-like, DEXD box c2 type Helicase superfamily 1/2, ATP-binding domain Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type Helicase superfamily 1/2, DinG/Rad3-like P-loop containing nucleoside triphosphate hydrolase RAD3-like helicase, DEAD
UniProtKB:A0A8M9PC39 InterPro 1203
UniProtKB:B7ZDD5 InterPro 1216
UniProtKB:A0A8M9PL91 InterPro 760
UniProtKB:A0AB32T1I3 InterPro 1370
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Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA brip1-201 (1) Ensembl 3,918 nt
mRNA brip1-202 (1) Ensembl 649 nt
mRNA brip1-203 (1) Ensembl 4,294 nt
mRNA brip1-204 (1) Ensembl 4,219 nt
mRNA brip1-205 (1) Ensembl 6,948 nt
1 - 5 of 8 Show all
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations