Gene

brip1

ID
ZDB-GENE-081107-11
Name
BRCA1 interacting helicase 1
Symbol
brip1 Nomenclature History
Previous Names
  • fancj (1)
  • Fanconi anemia, complementation group J
  • si:ch211-158l18.1
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to enable DNA helicase activity. Predicted to be involved in double-strand break repair involved in meiotic recombination and nucleotide-excision repair. Predicted to act upstream of or within nucleobase-containing compound metabolic process. Predicted to be active in nucleus. Is expressed in central nervous system; lens; oral epithelium; and pectoral fin fold. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group J; breast cancer; colorectal cancer; and thrombocytopenia. Orthologous to human BRIP1 (BRCA1 interacting helicase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from Titus et al., 2009
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Ramanagoudr-Bhojappa et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With brip1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
breast cancer Alliance {Breast cancer, early-onset, susceptibility to} 114480
Fanconi anemia complementation group J Alliance Fanconi anemia, complementation group J 609054
Associated With brip1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006554 Helicase-like, DEXD box c2 type
Domain IPR006555 ATP-dependent helicase, C-terminal
Domain IPR010614 DEAD2
Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
Domain IPR014013 Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type
Family IPR013020 ATP-dependent helicase Rad3/Chl1-like
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length ATP-dependent helicase, C-terminal ATP-dependent helicase Rad3/Chl1-like DEAD2 Helicase-like, DEXD box c2 type Helicase superfamily 1/2, ATP-binding domain Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type P-loop containing nucleoside triphosphate hydrolase
UniProtKB:B7ZDD5 1216
UniProtKB:A0A2R8QLG8 1198
UniProtKB:F8W319 163
UniProtKB:A0A2R8QLM4 1226
UniProtKB:A0A2R8S0B7 1229
UniProtKB:A0A2R8QCP4 1222
UniProtKB:A8QLH7 1217
UniProtKB:A0A2R8Q596 1217
UniProtKB:A0A2R8QEM7 1204
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations