Gene

syn1

ID
ZDB-GENE-081105-93
Name
synapsin I
Symbol
syn1 Nomenclature History
Previous Names
  • si:dkey-90n12.3 (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have ATP binding activity. Predicted to be involved in neurotransmitter secretion. Predicted to localize to synaptic vesicle membrane. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Is expressed in DEL; nervous system; spinal cord neural tube; and yolk syncytial layer. Orthologous to human SYN1 (synapsin I).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa7143Allele with one point mutationUnknownPremature StopENU
sa12369Allele with one point mutationUnknownPremature StopENU
sa21334Allele with one point mutationUnknownPremature StopENU
sa21335Allele with one point mutationUnknownPremature StopENU
sa34436Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With syn1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
non-syndromic X-linked intellectual disability 50 Alliance Intellectual developmental disorder, X-linked 50 300115
X-linked epilepsy with variable learning disabilities and behavior disorders Alliance Epilepsy, X-linked 1, with variable learning disabilities and behavior disorders 300491
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Associated With syn1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019735 Synapsin, conserved site
Domain IPR020897 Synapsin, pre-ATP-grasp domain
Domain IPR020898 Synapsin, ATP-binding domain
Family IPR001359 Synapsin
Homologous_superfamily IPR013815 ATP-grasp fold, subdomain 1
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Domain Details Per Protein
Protein Length ATP-grasp fold, subdomain 1 Pre-ATP-grasp domain superfamily Synapsin Synapsin, ATP-binding domain Synapsin, conserved site Synapsin, phosphorylation site Synapsin, pre-ATP-grasp domain
UniProtKB:B0UXI4 670
UniProtKB:A0A8M2BEL9 633
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 8
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA syn1-201 (1) Ensembl 4,981 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(10xUAS-E1B:syn1-EGFP)
  • Danio rerio
1Goode et al., 2020
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-90N12ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanSYN1X
Amino acid sequence comparison (1)
MouseSyn1X
Amino acid sequence comparison (1)
Citations
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