Gene
syn1
- ID
- ZDB-GENE-081105-93
- Name
- synapsin I
- Symbol
- syn1 Nomenclature History
- Previous Names
-
- si:dkey-90n12.3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity. Predicted to be involved in neurotransmitter secretion. Predicted to localize to synaptic vesicle membrane. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Is expressed in DEL; nervous system; spinal cord neural tube; and yolk syncytial layer. Orthologous to human SYN1 (synapsin I).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa7143 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa12369 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa21334 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa21335 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa34436 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
non-syndromic X-linked intellectual disability 50 | Alliance | Intellectual developmental disorder, X-linked 50 | 300115 |
X-linked epilepsy with variable learning disabilities and behavior disorders | Alliance | Epilepsy, X-linked 1, with variable learning disabilities and behavior disorders | 300491 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | ATP-grasp fold, subdomain 1 | Pre-ATP-grasp domain superfamily | Synapsin | Synapsin, ATP-binding domain | Synapsin, conserved site | Synapsin, phosphorylation site | Synapsin, pre-ATP-grasp domain |
---|---|---|---|---|---|---|---|---|
UniProtKB:B0UXI4
|
670 | |||||||
UniProtKB:A0A8M2BEL9
|
633 |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(10xUAS-E1B:syn1-EGFP) |
|
| 1 | Goode et al., 2020 |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-90N12 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001126437 (1) | 4981 nt | ||
Genomic | GenBank:CR376723 (1) | 213541 nt | ||
Polypeptide | UniProtKB:B0UXI4 (1) | 670 aa |
- Gabellini, C., Pucci, C., De Cesari, C., Martini, D., Di Lauro, C., Digregorio, M., Norton, W., Zippo, A., Sessa, A., Broccoli, V., Andreazzoli, M. (2022) CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene setd5 Leads to Social Impairments in Zebrafish. International Journal of Molecular Sciences. 24(1):
- Griffin, A., Carpenter, C., Liu, J., Paterno, R., Grone, B., Hamling, K., Moog, M., Dinday, M.T., Figueroa, F., Anvar, M., Ononuju, C., Qu, T., Baraban, S.C. (2021) Phenotypic analysis of catastrophic childhood epilepsy genes. Communications biology. 4:680
- Goode, C., Voeun, M., Ncube, D., Eisen, J., Washbourne, P., Tallafuss, A. (2020) Late onset of Synaptotagmin 2a expression at synapses relevant to social behavior. The Journal of comparative neurology. 529(9):2176-2188
- Xue, C., Wang, H.H., Zhu, J., Zhou, J. (2018) The expression patterns of vestigial like family member 4 genes in zebrafish embryogenesis. Gene expression patterns : GEP. 28:34-41
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Cheng, Y., Ekker, M., Chan, H.M. (2015) Relative developmental toxicities of pentachloroanisole and pentachlorophenol in a zebrafish model (Danio rerio). Ecotoxicology and environmental safety. 112C:7-14
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Garbarino, G., Costa, S., Pestarino, M., Candiani, S. (2014) Differential expression of synapsin genes during early zebrafish development. Neuroscience. 280:351-67
- Rodriguez, R.S., Haugen, R., Rueber, A., Huang, C.C. (2014) Reversible neuronal and muscular toxicity of caffeine in developing vertebrates. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 163:47-54
- Easley-Neal, C., Fierro, J., Buchanan, J., and Washbourne, P. (2013) Late Recruitment of Synapsin to Nascent Synapses Is Regulated by Cdk5. Cell Reports. 3(4):1199-1212
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