Gene
ranbp2
- ID
- ZDB-GENE-081104-93
- Name
- RAN binding protein 2
- Symbol
- ranbp2 Nomenclature History
- Previous Names
-
- nup358 (1)
- si:ch1073-55a19.2
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables SUMO ligase activity. Acts upstream of or within cell projection assembly. Is active in annulate lamellae. Is expressed widely. Human ortholog(s) of this gene implicated in brain disease and inflammatory myofibroblastic tumor. Orthologous to several human genes including RANBP2 (RAN binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Magre et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Magre et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Encephalopathy, acute, infection-induced, 3, susceptibility to} | 608033 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020892 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site |
| Domain | IPR000156 | Ran binding domain |
| Domain | IPR001876 | Zinc finger, RanBP2-type |
| Domain | IPR002130 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain |
| Domain | IPR022011 | Nup358/RanBP2 E3 ligase domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cyclophilin-like domain superfamily | Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site | Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain | Nup358/RanBP2 E3 ligase domain | PH-like domain superfamily | Ran binding domain | Ran binding protein RanBP1-like | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat | Zinc finger, RanBP2-type | Zinc finger, RanBP2-type superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QJW3 | InterPro | 2984 | |||||||||||
| UniProtKB:A0A8M1RKE0 | InterPro | 2958 | |||||||||||
| UniProtKB:A0A8M9QFP1 | InterPro | 2968 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ranbp2-201
(1)
|
Ensembl | 9,214 nt | ||
| mRNA |
ranbp2-202
(1)
|
Ensembl | 8,862 nt | ||
| mRNA |
ranbp2-203
(1)
|
Ensembl | 8,811 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-ranbp2 | polyclonal | Rabbit |
|
1 |
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Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-55A19 | ZFIN Curated Data | |
| Encodes | EST | wz13204 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021478795 (1) | 9313 nt | ||
| Genomic | GenBank:CU638712 (1) | 35166 nt | ||
| Polypeptide | UniProtKB:A0A8M9QJW3 (1) | 2984 aa |
- Morgan, K.J., Doggett, K., Geng, F., Mieruszynski, S., Whitehead, L., Smith, K.A., Hogan, B.M., Simons, C., Baillie, G.J., Molania, R., Papenfuss, A.T., Hall, T.E., Ober, E.A., Stainier, D.Y.R., Gong, Z., Heath, J.K. (2023) ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma. eLIFE. 12:
- Magre, I., Fandade, V., Damle, I., Banerjee, P., Yadav, S.K., Sonawane, M., Joseph, J. (2019) Nup358 regulates microridge length by controlling SUMOylation-dependent activity of aPKC in zebrafish epidermis. Journal of Cell Science. 132(12):
- Raman, R., Damle, I., Rote, R., Banerjee, S., Dingare, C., Sonawane, M. (2016) aPKC regulates apical localization of Lgl to restrict elongation of microridges in developing zebrafish epidermis. Nature communications. 7:11643
- Geisler, R., Rauch, G.J., Baier, H., van Bebber, F., Brobeta, L., Dekens, M.P., Finger, K., Fricke, C., Gates, M.A., Geiger, H., Geiger-Rudolph, S., Gilmour, D., Glaser, S., Gnugge, L., Habeck, H., Hingst, K., Holley, S., Keenan, J., Kirn, A., Knaut, H., Lashkari, D., Maderspacher, F., Martyn, U., Neuhauss, S., Neumann, C., Nicolson, T., Pelegri, F., Ray, R., Rick, J.M., Roehl, H., Roeser, T., Schauerte, H.E., Schier, A.F., Schönberger, U., Schönthaler, H.-B., Schulte-Merker, S., Seydler, C., Talbot, W.S., Weiler, C., Nüsslein-Volhard, C., and Haffter, P. (1999) A radiation hybrid map of the zebrafish genome. Nature Genetics. 23(1):86-89
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