Gene
tnfrsf11b
- ID
- ZDB-GENE-081104-76
- Name
- tumor necrosis factor receptor superfamily, member 11b
- Symbol
- tnfrsf11b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Acts upstream of or within response to mechanical stimulus. Is expressed in caudal fin; head; and scale. Human ortholog(s) of this gene implicated in Paget's disease of bone; Paget's disease of bone 5; and osteoarthritis. Orthologous to human TNFRSF11B (TNF receptor superfamily member 11b).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Paget's disease of bone 5 | Alliance | Paget disease of bone 5, juvenile-onset | 239000 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnfrsf11b-201
(1)
|
Ensembl | 2,330 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-tnfrsf11b | polyclonal | IgG | Rabbit |
|
Abcam plc
|
2 |
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-210B3 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| Genomic | GenBank:CU611039 (1) | 35305 nt |
- Daponte, V., Tonelli, F., Masiero, C., Syx, D., Exbrayat-Héritier, C., Biggiogera, M., Willaert, A., Rossi, A., Coucke, P.J., Ruggiero, F., Forlino, A. (2023) Cell differentiation and matrix organization are differentially affected during bone formation in osteogenesis imperfecta zebrafish models with different genetic defects impacting collagen type I structure. Matrix biology : journal of the International Society for Matrix Biology. 121:105-126
- Guo, W., Jin, P., Li, R., Huang, L., Liu, Z., Li, H., Zhou, T., Fang, B., Xia, L. (2023) Dynamic network biomarker identifies cdkn1a-mediated bone mineralization in the triggering phase of osteoporosis. Experimental & molecular medicine. 55(1):81-94
- Tonelli, F., Leoni, L., Daponte, V., Gioia, R., Cotti, S., Fiedler, I.A.K., Larianova, D., Willaert, A., Coucke, P.J., Villani, S., Busse, B., Besio, R., Rossi, A., Witten, P.E., Forlino, A. (2023) Zebrafish Tric-b is required for skeletal development and bone cells differentiation. Frontiers in endocrinology. 14:10029141002914
- Jimenez, E., Slevin, C.C., Song, W., Chen, Z., Frederickson, S.C., Gildea, D., Wu, W., Elkahloun, A.G., Ovcharenko, I., Burgess, S.M. (2022) A regulatory network of Sox and Six transcription factors initiate a cell fate transformation during hearing regeneration in adult zebrafish. Cell genomics. 2(9):
- Peng, C.H., Lin, W.Y., Li, C.Y., Dharini, K.K., Chang, C.Y., Hong, J.T., Lin, M.D. (2022) Gu Sui Bu (Drynaria fortunei J. Sm.) antagonizes glucocorticoid-induced mineralization reduction in zebrafish larvae by modulating the activity of osteoblasts and osteoclasts. Journal of ethnopharmacology. 297:115565
- Wang, F., Rong, P., Wang, J., Yu, X., Wang, N., Wang, S., Xue, Z., Chen, J., Meng, W., Peng, X. (2022) Anti-osteoporosis effects and regulatory mechanism of Lindera aggregata based on network pharmacology and experimental validation. Food & function. 13(11):6419-6432
- Xu, P., Lin, B., Deng, X., He, S., Chen, N., Wang, N. (2022) Anti-osteoporosis effects of Anemarrhenae Rhizoma / Phellodendri Chinensis Cortex herb pair and its major active components in diabetic rats and zebrafish. Journal of ethnopharmacology. 293:115269
- Han, Y., Shao, W., Zhong, D., Ma, C., Wei, X., Ahmed, A., Yu, T., Jing, W., Jing, L. (2021) Zebrafish mafbb Mutants Display Osteoclast Over-Activation and Bone Deformity Resembling Osteolysis in MCTO Patients. Biomolecules. 11(3):
- Carnovali, M., Banfi, G., Mariotti, M. (2020) Age-dependent modulation of bone metabolism in zebrafish scales as new model of male osteoporosis in lower vertebrates. GeroScience. 43(2):927-940
- Jiang, Y., Lu, Y., Jiang, X., Hu, J., Li, R., Liu, Y., Zhu, G., Rong, X. (2020) Glucocorticoids induce osteoporosis mediated by glucocorticoid receptor-dependent and -independent pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 125:109979
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