ZFIN is now using GRCz12tu for Genomic Data
Gene
rpe65c
- ID
- ZDB-GENE-081104-505
- Name
- retinoid isomerohydrolase RPE65 c
- Symbol
- rpe65c Nomenclature History
- Previous Names
-
- si:ch211-198n5.12 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity and retinol isomerase activity. Predicted to be involved in retinal metabolic process and zeaxanthin biosynthetic process. Located in cytosol and plasma membrane. Is expressed in Muller cell; retina; retinal ganglion cell layer; and retinal inner nuclear layer. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 2; autoimmune disease; retinitis pigmentosa; retinitis pigmentosa 20; and retinitis pigmentosa 87. Orthologous to human RPE65 (retinoid isomerohydrolase RPE65).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR004294 | Carotenoid oxygenase |
Domain Details Per Protein
| Protein | Additional Resources | Length | Carotenoid oxygenase |
|---|---|---|---|
| UniProtKB:A9C3R8 | InterPro |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rpe65c-201
(1)
|
Ensembl | 1,661 nt | ||
| mRNA |
rpe65c-202
(1)
|
Ensembl | 906 nt | ||
| mRNA |
rpe65c-203
(1)
|
Ensembl | 1,599 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-rpe65c | polyclonal | Rabbit |
|
1 |
Plasmids
No data available
- Genome Browsers