Gene
adamts10
- ID
- ZDB-GENE-081104-414
- Name
- ADAM metallopeptidase with thrombospondin type 1 motif, 10
- Symbol
- adamts10 Nomenclature History
- Previous Names
-
- si:dkey-45m5.4
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable metalloendopeptidase activity. Acts upstream of or within retina layer formation. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in several structures, including digestive system; eye; pleuroperitoneal region; presumptive retinal pigmented epithelium; and thymus. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome. Orthologous to human ADAMTS10 (ADAM metallopeptidase with thrombospondin type 1 motif 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Wareham et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa7130 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa9421 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa18917 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa31645 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa34374 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa38685 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Weill-Marchesani syndrome | Alliance | Weill-Marchesani syndrome 1, recessive | 277600 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | ADAMTS/ADAMTS-like | ADAMTS/ADAMTS-like, cysteine-rich domain 3 | ADAMTS/ADAMTS-like, Spacer 1 | ADAMTS and ADAMTS-like | ADAMTS, cysteine-rich domain 2 | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin | Peptidase M12B, propeptide | PLAC | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M1NG56 | InterPro | 1108 | |||||||||||
UniProtKB:A0A8M3AV42 | InterPro | 894 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
adamts10-201
(1)
|
Ensembl | 3,978 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-45M5 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001123274 (1) | 3978 nt | ||
Genomic | GenBank:BX511253 (1) | 216373 nt | ||
Polypeptide | UniProtKB:A0A8M1NG56 (1) | 1108 aa |
- Wareham, L.K., Whitener, A.E., Wu, H.J., Wu, S.Y., Mchaourab, H.S., Mortlock, D.P., Kuchtey, R.W., Kuchtey, J. (2022) Adamts10 controls transforming growth factor β family signaling that contributes to retinal ganglion cell development. Frontiers in molecular biosciences. 9:989851
- Johnston, E.F., Cadonic, I.G., Craig, P.M., Gillis, T.E. (2019) microRNA-29b knocks down collagen type I production in cultured rainbow trout (Oncorhynchus mykiss) cardiac fibroblasts. The Journal of experimental biology. 222(Pt 17):
- Brunet, F.G., Fraser, F.W., Binder, M.J., Smith, A.D., Kintakas, C., Dancevic, C.M., Ward, A.C., McCulloch, D.R. (2015) The evolutionary conservation of the A Disintegrin-like and Metalloproteinase domain with Thrombospondin-1 motif metzincins across vertebrate species and their expression in teleost zebrafish. BMC Evolutionary Biology. 15:22
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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