Gene

adamts10

ID

ZDB-GENE-081104-414

Name

ADAM metallopeptidase with thrombospondin type 1 motif, 10

Symbol

adamts10 Nomenclature History

Previous Names

si:dkey-45m5.4

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Is predicted to enable metalloendopeptidase activity. Involved in extracellular matrix organization. Acts upstream of or within proteolysis. Predicted to be located in extracellular region. Is expressed in several structures, including digestive system; eye; heart; pleuroperitoneal region; and thymus. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome. Orthologous to human ADAMTS10 (ADAM metallopeptidase with thrombospondin type 1 motif 10).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Brunet et al., 2015

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adamts10 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Weill-Marchesani syndrome	Alliance	Weill-Marchesani syndrome 1, recessive	277600

Associated With adamts10 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001590	Peptidase M12B, ADAM/reprolysin
Domain	IPR002870	Peptidase M12B, propeptide
Domain	IPR010909	PLAC
Family	IPR013273	ADAMTS/ADAMTS-like
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily
Homologous_superfamily	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily
Repeat	IPR000884	Thrombospondin type-1 (TSP1) repeat