Gene
adamts10
- ID
- ZDB-GENE-081104-414
- Name
- ADAM metallopeptidase with thrombospondin type 1 motif, 10
- Symbol
- adamts10 Nomenclature History
- Previous Names
-
- si:dkey-45m5.4
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Is predicted to enable metalloendopeptidase activity. Involved in extracellular matrix organization. Acts upstream of or within proteolysis. Predicted to be located in extracellular region. Is expressed in several structures, including digestive system; eye; heart; pleuroperitoneal region; and thymus. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome. Orthologous to human ADAMTS10 (ADAM metallopeptidase with thrombospondin type 1 motif 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Brunet et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Weill-Marchesani syndrome | Alliance | Weill-Marchesani syndrome 1, recessive | 277600 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001590 | Peptidase M12B, ADAM/reprolysin |
Domain | IPR002870 | Peptidase M12B, propeptide |
Domain | IPR010909 | PLAC |
Family | IPR013273 | ADAMTS/ADAMTS-like |
Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
Domain Details Per Protein
Protein | Length | ADAMTS/ADAMTS-like | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin | Peptidase M12B, propeptide | PLAC | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
---|---|---|---|---|---|---|---|---|
UniProtKB:B0S6F1
|
1108 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
adamts10-201
(1)
|
3978 nt |
Interactions and Pathways
No data available
Plasmids
No data available