Gene
gnaq
- ID
- ZDB-GENE-081104-25
- Name
- guanine nucleotide binding protein (G protein), q polypeptide
- Symbol
- gnaq Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; GTPase activator activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in Golgi apparatus and nuclear membrane. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including gonad; heart; immune system; liver; and nervous system. Human ortholog(s) of this gene implicated in Sturge-Weber syndrome; congestive heart failure; and familial multiple nevi flammei. Orthologous to human GNAQ (G protein subunit alpha q).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gnaq | Zebrafish Nomenclature Committee |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial multiple nevi flammei | Alliance | Capillary malformations, congenital, 1, somatic, mosaic | 163000 |
| Sturge-Weber syndrome | Alliance | Sturge-Weber syndrome, somatic, mosaic | 185300 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR000654 | G-protein alpha subunit, group Q |
| Family | IPR001019 | Guanine nucleotide binding protein (G-protein), alpha subunit |
| Homologous_superfamily | IPR011025 | G protein alpha subunit, helical insertion |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | G-protein alpha subunit, group Q | G protein alpha subunit, helical insertion | Guanine nucleotide binding protein (G-protein), alpha subunit | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|
| UniProtKB:B8JLJ7 | InterPro | 359 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(cryaa:Venus,mitfa:gnaq_Q209P) |
|
| 3 | Mouti et al., 2016 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001144799 (1) | 1745 nt | ||
| Genomic | GenBank:CU468920 (1) | 93429 nt | ||
| Polypeptide | UniProtKB:B8JLJ7 (1) | 359 aa |
- Shibata, T., Kawakami, K., Kawana, H., Aoki, J., Inoue, A. (2022) Phenotypic evaluation of constitutive GPCR/G-protein signaling in zebrafish embryos and larvae. Biochemical and Biophysical Research Communications. 602:70-76
- Wang, C., Yang, L., Xiao, T., Li, J., Liu, Q., Xiong, S. (2022) Identification and expression analysis of zebrafish gnaq in the hypothalamic-Pituitary-Gonadal axis. Frontiers in genetics. 13:10157961015796
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Sun, C.C., Zhou, Z.Q., Chen, Z.L., Zhu, R.K., Yang, D., Peng, X.Y., Zheng, L., Tang, C.F. (2021) Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish. Biology. 10(8):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Takeuchi, M., Yamaguchi, S., Sakakibara, M., Hayashi, T., Matsuda, K., Hara, Y., Tanegashima, C., Shimizu, T., Kuraku, S., Hibi, M. (2017) Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. The Journal of comparative neurology. 525(7):1558-1585
- David, A.P., Margarit, E., Domizi, P., Banchio, C., Armas, P., Calcaterra, N.B. (2016) G-quadruplexes as novel cis-elements controlling transcription during embryonic development. Nucleic acids research. 44(9):4163-73
- Mouti, M.A., Dee, C., Coupland, S.E., Hurlstone, A.F. (2016) Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQQ209P-driven uveal melanomas in zebrafish. Oncotarget. 7(26):39654-39670
- Smith, L.C., Clark, J.C., Bisesi, J.H., Ferguson, P.L., Sabo-Attwood, T. (2016) Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 19:159-73
- Suzuki, H., Nikaido, M., Hagino-Yamagishi, K., Okada, N. (2015) Distinct functions of two olfactory marker protein genes derived from teleost-specific whole genome duplication. BMC Evolutionary Biology. 15:245
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