Gene
cux2b
- ID
- ZDB-GENE-081104-176
- Name
- cut-like homeobox 2b
- Symbol
- cux2b Nomenclature History
- Previous Names
-
- cux2
- si:ch211-218i18.2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have RNA polymerase II regulatory region sequence-specific DNA binding activity. Predicted to be involved in Golgi vesicle transport and negative regulation of transcription by RNA polymerase II. Predicted to localize to Golgi membrane and nucleus. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy. Is expressed in eye; hindbrain; and telencephalon. Orthologous to human CUX2 (cut like homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Takano et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Charlton-Perkins et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 67 | Alliance | Developmental and epileptic encephalopathy 67 | 618141 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CUT domain | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Lambda repressor-like, DNA-binding domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B1R7
|
1456 |
Interactions and Pathways
No data available
Plasmids
No data available