ZFIN is now using GRCz12tu for Genomic Data
Gene
maptb
- ID
- ZDB-GENE-081027-2
- Name
- microtubule-associated protein tau b
- Symbol
- maptb Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable enzyme inhibitor activity; microtubule binding activity; and microtubule stabilizing activity. Predicted to be involved in microtubule cytoskeleton organization; neuron projection development; and regulation of microtubule-based movement. Predicted to be located in cytoplasm and microtubule. Predicted to be active in axon and microtubule cytoskeleton. Is expressed in nervous system; shield; spinal cord neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Orthologous to human MAPT (microtubule associated protein tau).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| frontotemporal dementia 1 | Alliance | Frontotemporal dementia 1, with or without parkinsonism | 600274 |
| late onset Parkinson's disease | Alliance | {Parkinson disease, susceptibility to} | 168600 |
| Pick's disease | Alliance | Pick disease | 172700 |
| progressive supranuclear palsy | Alliance | Supranuclear palsy, progressive | 601104 |
| Supranuclear palsy, progressive atypical | 260540 |
Domain, Family, and Site Summary
Domain Details Per Protein
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
maptb-201
(1)
|
Ensembl | 3,023 nt | ||
| mRNA |
maptb-202
(1)
|
Ensembl | 746 nt | ||
| mRNA |
maptb-203
(1)
|
Ensembl | 1,266 nt | ||
| mRNA |
maptb-204
(1)
|
Ensembl | 719 nt | ||
| mRNA |
maptb-205
(1)
|
Ensembl | 800 nt | ||
| mRNA |
maptb-206
(1)
|
Ensembl | 4,792 nt | ||
| mRNA |
maptb-207
(1)
|
Ensembl | 804 nt | ||
| mRNA |
maptb-209
(1)
|
Ensembl | 3,126 nt | ||
| mRNA |
maptb-210
(1)
|
Ensembl | 3,222 nt | ||
| ncRNA |
maptb-006
(1)
|
Ensembl | 1,383 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers