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ZIRC
ZFIN ID: ZDB-GENE-081027-2
Gene Name: microtubule-associated protein tau b
Gene Symbol: maptb    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization and neuron projection development. Predicted to localize to the neuron projection. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Is expressed in nervous system; shield; spinal cord neural tube; and trigeminal placode. Orthologous to human MAPT (microtubule associated protein tau).
Genome Resources: Alliance (1),  Gene:567833 (1),  Ensembl(GRCz11):ENSDARG00000087616 (2)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH maptb HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
frontotemporal dementia Alliance Dementia, frontotemporal, with or without parkinsonism 600274
late onset Parkinson's disease Alliance {Parkinson disease, susceptibility to} 168600
Pick's disease Alliance Pick disease 172700
progressive supranuclear palsy Alliance Supranuclear palsy, progressive 601104
Supranuclear palsy, progressive atypical 260540
DISEASE ASSOCIATED WITH maptb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process microtubule cytoskeleton organization (more)
Cellular Component cytoplasm (more)
Molecular Function microtubule binding (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001084 (1)
  • InterPro:IPR027324 (1)
  • PROSITE:PS00229 (1)
  • PROSITE:PS51491 (1)
  • Pfam:PF00418 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA maptb-202 (1)    Ensembl 746
    maptb-203 (1)    Ensembl 1266
    maptb-204 (1)    Ensembl 719
    maptb-205 (1)    Ensembl 800
    maptb-206 (1)    Ensembl 4792
    maptb-207 (1)    Ensembl 804
    ncRNA maptb-006 (1) 1383
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM maptb No data available
    MARKER RELATIONSHIPS
    maptb Contained in: [BAC] CH73-176F10 (1) (order this), CH211-239N21 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_005171597 (1) 2521 bp
    Genomic GenBank:BX649538 (1) 147441 bp
    Select Tool
    Polypeptide UniProtKB:E7F9D4 (1) 778 aa
    Sequence Clusters UniGene:82673 (1)
    Sequence Information (all 36)
    ORTHOLOGY for maptb ( Chr: 3 )
    CITATIONS (21)