Gene
gra
- ID
- ZDB-GENE-081022-203
- Name
- granulito
- Symbol
- gra Nomenclature History
- Previous Names
-
- zgc:195256
- zgc:195266
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable eukaryotic initiation factor 4E binding activity. Predicted to be involved in negative regulation of translational initiation. Predicted to act upstream of or within negative regulation of translation. Located in P granule. Is expressed in blastomere and primordial germ cell. Orthologous to human C8orf88 (chromosome 8 open reading frame 88).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa36077 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR008606 | Eukaryotic translation initiation factor 4E binding |
Domain Details Per Protein
| Protein | Additional Resources | Length | Eukaryotic translation initiation factor 4E binding |
|---|---|---|---|
| UniProtKB:B3DKF4 | InterPro | 141 |
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-193P21 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-43F15 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195256 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195266 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001100948 (1) | 1922 nt | ||
| Genomic | GenBank:CU138519 | 146595 nt | ||
| Polypeptide | UniProtKB:B3DKF4 (1) | 141 aa |
No data available
- Hansen, C.L., Chamberlain, T.J., Trevena, R.L., Kurek, J.E., Pelegri, F. (2021) Conserved germ plasm characteristics across the Danio and Devario lineages. Genesis (New York, N.Y. : 2000). 59(10):e23452
- Mo, C., Li, W., Jia, K., Liu, W., Yi, M. (2021) Proper Balance of Small GTPase rab10 Is Critical for PGC Migration in Zebrafish. International Journal of Molecular Sciences. 22(21):
- Vong, Y.H., Sivashanmugam, L., Leech, R., Zaucker, A., Jones, A., Sampath, K. (2021) The RNA-binding protein Igf2bp3 is critical for embryonic and germline development in zebrafish. PLoS Genetics. 17:e1009667
- Roovers, E.F., Kaaij, L.J.T., Redl, S., Bronkhorst, A.W., Wiebrands, K., de Jesus Domingues, A.M., Huang, H.Y., Han, C.T., Riemer, S., Dosch, R., Salvenmoser, W., Grün, D., Butter, F., van Oudenaarden, A., Ketting, R.F. (2018) Tdrd6a Regulates the Aggregation of Buc into Functional Subcellular Compartments that Drive Germ Cell Specification. Developmental Cell. 46:285-301.e9
- Gross-Thebing, T., Yigit, S., Pfeiffer, J., Reichman-Fried, M., Bandemer, J., Ruckert, C., Rathmer, C., Goudarzi, M., Stehling, M., Tarbashevich, K., Seggewiss, J., Raz, E. (2017) The Vertebrate Protein Dead End Maintains Primordial Germ Cell Fate by Inhibiting Somatic Differentiation. Developmental Cell. 43:704-715.e5
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gross-Thebing, T., Paksa, A., Raz, E. (2014) Simultaneous high-resolution detection of multiple transcripts combined with localization of proteins in whole-mount embryos. BMC Biology. 12:55
- Hartwig, J., Tarbashevich, K., Seggewiß, J., Stehling, M., Bandemer, J., Grimaldi, C., Paksa, A., Groß-Thebing, T., Meyen, D., Raz, E. (2014) Temporal control over the initiation of cell motility by a regulator of G-protein signaling. Proceedings of the National Academy of Sciences of the United States of America. 111(31):11389-94
- Boldajipour, B., Mahabaleshwar, H., Kardash, E., Reichman-Fried, M., Blaser, H., Minina, S., Wilson, D., Xu, Q., and Raz, E. (2008) Control of chemokine-guided cell migration by ligand sequestration. Cell. 132(3):463-473
- Strasser, M.J., Mackenzie, N.C., Dumstrei, K., Nakkrasae, L.I., Stebler, J., and Raz, E. (2008) Control over the morphology and segregation of Zebrafish germ cell granules during embryonic development. BMC Developmental Biology. 8:58
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