Gene

ptgdsa

ID

ZDB-GENE-081022-118

Name

prostaglandin D2 synthase a

Symbol

ptgdsa Nomenclature History

Previous Names

im:7160217
zgc:194505
zgc:194526

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable small molecule binding activity. Predicted to be located in extracellular region. Is expressed in yolk syncytial layer. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PTGDS (prostaglandin D2 synthase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7160217 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa16004	Allele with one point mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With ptgdsa Human Ortholog

No data available

Associated With ptgdsa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR022272	Lipocalin family conserved site
Domain	IPR000566	Lipocalin/cytosolic fatty-acid binding domain
Family	IPR002345	Lipocalin
Homologous_superfamily	IPR012674	Calycin

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Domain Details Per Protein

Protein	Additional Resources	Length	Calycin	Lipocalin	Lipocalin/cytosolic fatty-acid binding domain	Lipocalin family conserved site
UniProtKB:B3DI79	InterPro	190

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 10

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	ptgdsa-201 (1) Ensembl	Ensembl		936 nt	Select Tool ZFIN BLAST
mRNA	ptgdsa-202 (1) Ensembl	Ensembl		734 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-21P9	BX005370	ZFIN Curated Data
Encodes	EST	IMAGE:7160217	CK695374	Thisse et al., 2004
Encodes	cDNA	MGC:194505	BC163029	ZFIN Curated Data
Encodes	cDNA	MGC:194526	BC163043	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001199991 (1)	841 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX005370 (1)	208765 nt	Select Tool MegaBLAST
Polypeptide	UniProtKB:B3DI79 (1)	190 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	PTGDS	9	Ensembl:ENSG00000107317 Gene:5730 HGNC:9592 OMIM:176803	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Ptgds	2	Ensembl:ENSMUSG00000015090 Gene:19215 MGI:99261	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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