Gene

casp20

ID

ZDB-GENE-081022-114

Name

caspase 20, apoptosis-related cysteine peptidase

Symbol

casp20 Nomenclature History

Previous Names

zgc:194469 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to enable cysteine-type endopeptidase activity involved in apoptotic signaling pathway and death effector domain binding activity. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and apoptotic process. Predicted to act upstream of or within proteolysis and regulation of apoptotic process. Predicted to be active in cytoplasm. Is expressed in gut; nervous system; pharyngeal arch; and vasculature.

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from Spead et al., 2018

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With casp20 Human Ortholog

No data available

Associated With casp20 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR033139	Peptidase family C14A, cysteine active site
Domain	IPR001309	Peptidase C14, p20 domain
Domain	IPR001315	CARD domain
Domain	IPR002138	Peptidase C14, caspase non-catalytic subunit p10
Domain	IPR011600	Peptidase C14, caspase domain
Domain	IPR015917	Peptidase C14A, caspase catalytic domain
Homologous_superfamily	IPR011029	Death-like domain superfamily
Homologous_superfamily	IPR029030	Caspase-like domain superfamily

Domain Details Per Protein

Protein	Length	CARD domain	Caspase-like domain superfamily	Death-like domain superfamily	Peptidase C14A, caspase catalytic domain	Peptidase C14, caspase domain	Peptidase C14, caspase non-catalytic subunit p10	Peptidase C14, p20 domain	Peptidase family C14A, cysteine active site
UniProtKB:A0A0R4IJE4 InterPro	347
UniProtKB:B3DJZ5 InterPro	347

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	casp20-201 (1) Ensembl	Ensembl	1,044 nt	Select Tool ZFIN BLAST
mRNA	casp20-202 (1) Ensembl	Ensembl	4,420 nt	Select Tool ZFIN BLAST
mRNA	casp20-203 (1) Ensembl	Ensembl	738 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations