ZFIN is now using GRCz12tu for Genomic Data
Gene
cul3b
- ID
- ZDB-GENE-081007-1
- Name
- cullin 3b
- Symbol
- cul3b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be located in cytoplasm. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with or without autism or seizures and pseudohypoaldosteronism. Orthologous to human CUL3 (cullin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neurodevelopmental disorder with or without autism or seizures | Alliance | Neurodevelopmental disorder with or without autism or seizures | 619239 |
| Pseudohypoaldosteronism, type IIE | 614496 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR016157 | Cullin, conserved site |
| Domain | IPR001373 | Cullin, N-terminal |
| Domain | IPR016158 | Cullin homology domain |
| Domain | IPR019559 | Cullin protein, neddylation domain |
| Family | IPR045093 | Cullin |
| Homologous_superfamily | IPR016159 | Cullin repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036317 | Cullin homology domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cullin | Cullin, conserved site | Cullin homology domain | Cullin homology domain superfamily | Cullin, N-terminal | Cullin protein, neddylation domain | Cullin repeat-like-containing domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B3DIU1 | InterPro | 766 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers