Gene

lepa

ID
ZDB-GENE-081001-1
Name
leptin a
Symbol
lepa Nomenclature History
Previous Names
  • lep
  • ob (1)
  • si:dkey-98o11.2
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to enable hormone activity. Acts upstream of or within camera-type eye development; inner ear development; and nervous system development. Predicted to be located in extracellular region. Is expressed in several structures, including brain; digestive system; heart; integument; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human LEP (leptin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
20 figures from 18 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
18 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
cy50Allele with one deletionExon 2UnknownTALEN
nz301Allele with one insertionUnknownUnknownCRISPR
umo37Allele with one deletionUnknownFrameshift, Premature StopCRISPR
China Zebrafish Resource Center (CZRC) (order this)
vu621Allele with one deletionUnknownUnknownCRISPR
vu622Allele with one deletionUnknownUnknownCRISPR
1 - 5 of 5
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-lepa (2)
CRISPR2-lepa (2)
CRISPR3-lepa
    		 (2)
    CRISPR4-lepa
      		Hu et al., 2022
      CRISPR5-lepa
        		Hu et al., 2022
        CRISPR6-lepa (2)
        MO1-lepaN/AYu et al., 2012
        MO2-lepaN/A (3)
        MO3-lepaN/ALiu et al., 2012
        MO4-lepaN/ALiu et al., 2012
        1 - 10 of 12
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        Human Disease
        Associated With lepa Human Ortholog
        Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
        congenital leptin deficiency Alliance Obesity, morbid, due to leptin deficiency 614962
        1 - 1 of 1
        Associated With lepa Via Experimental Models
        No data available
        Gene Ontology
        Protein Domains
        Domain, Family, and Site Summary
        Type InterPro ID Name
        Family IPR000065 Leptin
        Homologous_superfamily IPR009079 Four-helical cytokine-like, core
        1 - 2 of 2
        Domain Details Per Protein
        Protein Additional Resources Length Four-helical cytokine-like, core Leptin
        UniProtKB:Q0D250 InterPro 166
        1 - 1 of 1
        Transcripts
        Genome Browsers
        Type Name Annotation Method Has Havana Data Length (nt) Analysis
        mRNA lepa-201 (1)
        Ensembl
        		Ensembl 501 nt
        ZFIN BLAST
        1 - 1 of 1
        Interactions and Pathways
        No data available
        Antibodies
        Name Type Antigen Genes Isotype Host Organism Assay Source Citations
        Ab1-lepa polyclonal IgG Rabbit
        • WB
        		 1
        1 - 1 of 1
        Plasmids
        No data available
        Constructs
        No data available
        Marker Relationships
        Sequences
        Orthology
        Comparative Orthology
        Alliance
        Gene Tree
        Ensembl
        Citations
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