Gene

hspg2

ID
ZDB-GENE-080807-4
Name
heparan sulfate proteoglycan 2
Symbol
hspg2 Nomenclature History
Previous Names
  • perlecan (1)
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity. Involved in several processes, including blood vessel endothelial cell migration; endothelial cell proliferation; and skeletal muscle tissue development. Human ortholog(s) of this gene implicated in Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; and osteochondrodysplasia. Is expressed in several structures, including axial vasculature; immature eye; intestine; trunk; and trunk musculature. Orthologous to human HSPG2 (heparan sulfate proteoglycan 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hspg2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Schwartz-Jampel syndrome 1 Alliance Schwartz-Jampel syndrome, type 1 255800
Silverman-Handmaker type dyssegmental dysplasia Alliance Dyssegmental dysplasia, Silverman-Handmaker type 224410
Associated With hspg2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
Domain IPR000034 Laminin IV
Domain IPR000082 SEA domain
Domain IPR000742 EGF-like domain
Domain IPR001791 Laminin G domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR013151 Immunoglobulin
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036055 LDL receptor-like superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Domain Details Per Protein
Protein Length Concanavalin A-like lectin/glucanase domain superfamily EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain Growth factor receptor cysteine-rich domain superfamily Immunoglobulin Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Laminin G domain Laminin IV LDL receptor-like superfamily Low-density lipoprotein (LDL) receptor class A, conserved site Low-density lipoprotein (LDL) receptor class A repeat SEA domain
UniProtKB:F1R5K7 3397
UniProtKB:F1RCP6 3419
UniProtKB:B2RZI0 3407
UniProtKB:A0A0R4IZA6 3462
UniProtKB:B0LVF1 656
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-hspg2 polyclonal Rabbit
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations