Gene

hspg2

ID

ZDB-GENE-080807-4

Name

heparan sulfate proteoglycan 2

Symbol

hspg2 Nomenclature History

Previous Names

perlecan (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity. Involved in several processes, including blood vessel endothelial cell migration; endothelial cell proliferation; and skeletal muscle tissue development. Human ortholog(s) of this gene implicated in Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; and osteochondrodysplasia. Is expressed in several structures, including axial vasculature; immature eye; intestine; trunk; and trunk musculature. Orthologous to human HSPG2 (heparan sulfate proteoglycan 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 19 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hspg2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Schwartz-Jampel syndrome 1	Alliance	Schwartz-Jampel syndrome, type 1	255800
Silverman-Handmaker type dyssegmental dysplasia	Alliance	Dyssegmental dysplasia, Silverman-Handmaker type	224410

Associated With hspg2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
Domain	IPR000034	Laminin IV
Domain	IPR000082	SEA domain
Domain	IPR000742	EGF-like domain
Domain	IPR001791	Laminin G domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR002049	Laminin-type EGF domain
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Domain	IPR013106	Immunoglobulin V-set domain
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036055	LDL receptor-like superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily
Repeat	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat

Domain Details Per Protein

Protein	Length	Concanavalin A-like lectin/glucanase domain superfamily	EGF-like calcium-binding domain	EGF-like domain	Growth factor receptor cysteine-rich domain superfamily	Immunoglobulin I-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin subtype	Immunoglobulin subtype 2	Immunoglobulin V-set domain	Laminin G domain	Laminin IV	Laminin-type EGF domain	LDL receptor-like superfamily	Low-density lipoprotein (LDL) receptor class A, conserved site	Low-density lipoprotein (LDL) receptor class A repeat	SEA domain
UniProtKB:A0A8M3ANS4 InterPro	3554
UniProtKB:A0A8M9PWW1 InterPro	3691
UniProtKB:A0A8M9PTK3 InterPro	3685
UniProtKB:A0A8M9P5I6 InterPro	3682
UniProtKB:A0A8M9PFI3 InterPro	3681
UniProtKB:A0A8M9PFI8 InterPro	3502
UniProtKB:A0A8M9P5J1 InterPro	3503
UniProtKB:A0A8M3ANR9 InterPro	3700
UniProtKB:A0A8M9PL79 InterPro	3675
UniProtKB:A0A8M9PWW5 InterPro	3658
UniProtKB:A0A8M3AYK3 InterPro	3689
UniProtKB:A0A8M9PTJ8 InterPro	3700
UniProtKB:A0A8M9P5I3 InterPro	3695
UniProtKB:A0A8M3B691 InterPro	3582
UniProtKB:A0A8M9PWV8 InterPro	3701
UniProtKB:A0A8M3AN20 InterPro	3604
UniProtKB:A0A8M3AVI2 InterPro	3688
UniProtKB:A0A8M9PFH8 InterPro	3692

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	hspg2-202 (1) Ensembl	Havana	10194 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	hspg2-203 (1) Ensembl	Havana	10833 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-hspg2	polyclonal	hspg2		Rabbit	IHC		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations