Gene

ralgapa1

ID

ZDB-GENE-080806-1

Name

Ral GTPase activating protein catalytic subunit alpha 1

Symbol

ralgapa1 Nomenclature History

Previous Names

garnl1
tulip1 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable GTPase activator activity. Acts upstream of or within brain development. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in head. Orthologous to human RALGAPA1 (Ral GTPase activating protein catalytic subunit alpha 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Shimojima et al., 2009

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Shimojima et al., 2009
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ralgapa1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with hypotonia, neonatal respiratory insufficiency, and thermodysregulation	618797

Associated With ralgapa1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000331	Rap/Ran-GAP domain
Domain	IPR046859	Ral GTPase-activating protein subunit alpha/beta, N-terminal domain
Family	IPR027107	Tuberin/Ral GTPase-activating protein subunit alpha
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR035974	Rap/Ran-GAP superfamily

Domain Details Per Protein

Protein	Length	Armadillo-type fold	Ral GTPase-activating protein subunit alpha/beta, N-terminal domain	Rap/Ran-GAP domain	Rap/Ran-GAP superfamily	Tuberin/Ral GTPase-activating protein subunit alpha
UniProtKB:A0A8M9P0D3 InterPro	2471
UniProtKB:A0A8M9PL41 InterPro	2499
UniProtKB:A0A8M9PL46 InterPro	2105
UniProtKB:A0A8M9PEK0 InterPro	2518
UniProtKB:A0A8M9PP64 InterPro	2124
UniProtKB:A0A8M9P0D7 InterPro	2066
UniProtKB:A0A8M9PEK4 InterPro	2171
UniProtKB:A0A8M9PP58 InterPro	2515
UniProtKB:A0A8M9P993 InterPro	2460
UniProtKB:A0A8M9P998 InterPro	2152

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ralgapa1-201 (1) Ensembl	Ensembl	6,846 nt	Select Tool ZFIN BLAST
mRNA	ralgapa1-202 (1) Ensembl	Ensembl	6,344 nt	Select Tool ZFIN BLAST
mRNA	ralgapa1-203 (1) Ensembl	Ensembl	7,844 nt	Select Tool ZFIN BLAST
mRNA	ralgapa1-204 (1) Ensembl	Ensembl	593 nt	Select Tool ZFIN BLAST
mRNA	ralgapa1-206 (1) Ensembl	Ensembl	926 nt	Select Tool ZFIN BLAST
mRNA	ralgapa1-207 (1) Ensembl	Ensembl	6,459 nt	Select Tool ZFIN BLAST
mRNA	ralgapa1-208 (1) Ensembl	Ensembl	6,366 nt	Select Tool ZFIN BLAST
ncRNA	ralgapa1-004 (1) Ensembl	Ensembl	422 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations