Gene

cyfip2

ID
ZDB-GENE-080724-2
Name
cytoplasmic FMR1 interacting protein 2
Symbol
cyfip2 Nomenclature History
Previous Names
  • nev (1)
  • nevermind (1)
  • zgc:194528
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have Rac GTPase binding activity. Involved in retina layer formation; retinal ganglion cell axon guidance; and startle response. Predicted to localize to cytoplasm. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 65. Orthologous to human CYFIP2 (cytoplasmic FMR1 interacting protein 2).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
19 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cyfip2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
developmental and epileptic encephalopathy 65 Alliance Developmental and epileptic encephalopathy 65 618008
Associated With cyfip2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR009828 CYRIA/CYRIB , Rac1 binding domain
Family IPR008081 Cytoplasmic FMR1-interacting
Domain Details Per Protein
Protein Length CYRIA/CYRIB , Rac1 binding domain Cytoplasmic FMR1-interacting
UniProtKB:A0A2R8PX02 1254
UniProtKB:A5A5E1 1253
UniProtKB:B3DIT1 1252
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cyfip2 polyclonal IgG Rabbit
  • IHC
Abcam plc
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations