Gene
cyfip2
- ID
- ZDB-GENE-080724-2
- Name
- cytoplasmic FMR1 interacting protein 2
- Symbol
- cyfip2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Involved in retina layer formation; retinal ganglion cell axon guidance; and startle response. Predicted to localize to neuron projection and synapse. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 65. Is expressed in central nervous system and retina. Orthologous to human CYFIP2 (cytoplasmic FMR1 interacting protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 65 | Alliance | Developmental and epileptic encephalopathy 65 | 618008 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CYRIA/CYRIB, Rac1 binding domain | Cytoplasmic FMR1-interacting |
|---|---|---|---|
|
UniProtKB:A0A8M3AS06
|
1251 | ||
|
UniProtKB:A5A5E1
|
1253 | ||
|
UniProtKB:B3DIT1
|
1252 | ||
|
UniProtKB:A0A8M3AP56
|
1016 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
cyfip2-201
(1)
|
Havana | 4023 nt | |
| mRNA |
cyfip2-202
(1)
|
Havana | 5369 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cyfip2 | polyclonal | IgG | Rabbit |
|
Abcam plc
|
2 |
Plasmids
No data available