Gene

cert1a

ID

ZDB-GENE-080724-10

Name

ceramide transporter 1a

Symbol

cert1a Nomenclature History

Previous Names

col4a3bp
col4a3bpa
gpbpΔ26
gpbp (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable ceramide 1-phosphate binding activity and ceramide 1-phosphate transfer activity. Predicted to be involved in ER to Golgi ceramide transport and intermembrane lipid transfer. Predicted to act upstream of or within lipid transport and muscle organ development. Predicted to be located in Golgi apparatus. Predicted to be active in cytosol. Is expressed in immature eye. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 34. Orthologous to human CERT1 (ceramide transporter 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Granero-Moltó et al., 2008

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Granero-Moltó et al., 2008
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cert1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 34	Alliance	Neurodevelopmental disorder with hypotonia, speech delay, and dysmorphic facies	616351

Associated With cert1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR002913	START domain
Domain	IPR041952	STARD11, START domain
Family	IPR051213	START domain-containing lipid transfer
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR023393	START-like domain superfamily

Domain Details Per Protein

Protein	Length	PH-like domain superfamily	Pleckstrin homology domain	STARD11, START domain	START domain	START domain-containing lipid transfer	START-like domain superfamily
UniProtKB:F8W2V5 InterPro	620
UniProtKB:Q5M7Y0 InterPro	620
UniProtKB:A0A2R9YJF5 InterPro	594

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cert1a-206 (1) Ensembl	Ensembl	5,357 nt	Select Tool ZFIN BLAST
mRNA	cert1a-207 (1) Ensembl	Ensembl	6,630 nt	Select Tool ZFIN BLAST
mRNA	col4a3bpa-201 (1) Ensembl	Ensembl	1,785 nt	Select Tool ZFIN BLAST
mRNA	col4a3bpa-202 (1) Ensembl	Ensembl	912 nt	Select Tool ZFIN BLAST
mRNA	col4a3bpa-204 (1) Ensembl	Ensembl	3,405 nt	Select Tool ZFIN BLAST
mRNA	col4a3bpa-205 (1) Ensembl	Ensembl	1,235 nt	Select Tool ZFIN BLAST
ncRNA	col4a3bpa-005 (1) Ensembl	Ensembl	390 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
AB1-col4a3bp	monoclonal	cert1a			IHC WB		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations