Gene
ulk1a
- ID
- ZDB-GENE-080723-31
- Name
- unc-51 like autophagy activating kinase 1a
- Symbol
- ulk1a Nomenclature History
- Previous Names
-
- zgc:195008
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation and regulation of autophagy. Is expressed in liver. Orthologous to human ULK1 (unc-51 like autophagy activating kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026581Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026582Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa7155 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa9810 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13161 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17536 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa25404 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34473 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR022708 | Serine/threonine-protein kinase Atg1-like, tMIT domain |
| Domain | IPR048941 | ATG1-like, MIT domain 2 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ATG1-like, MIT domain 2 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinase Atg1-like, tMIT domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:B3DJH7 | InterPro | 927 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-227I14 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195008 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001130631 (1) | 3405 nt | ||
| Genomic | GenBank:AL929056 (2) | 157468 nt | ||
| Polypeptide | UniProtKB:B3DJH7 (1) | 927 aa |
- Zhu, P., Li, J., Yan, F., Islam, S., Lin, X., Xu, X. (2024) Allelic heterogeneity of TTNtv cardiomyopathy can be modeled in adult zebrafish. JCI insight. 9(7):
- Ezhkova, D., Schwarzer, S., Spieß, S., Geffarth, M., Machate, A., Zöller, D., Stucke, J., Alexopoulou, D., Lesche, M., Dahl, A., Hans, S. (2023) Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish. Biology Open. 12(6):
- Bu, H., Ding, Y., Li, J., Zhu, P., Shih, Y.H., Wang, M., Zhang, Y., Lin, X., Xu, X. (2021) Inhibition of mTOR or MAPK ameliorates vmhcl/myh7 cardiomyopathy in zebrafish. JCI insight. 6(24):
- Castillo-Castellanos, F., Ramírez, L., Lomelí, H. (2021) zmiz1a zebrafish mutants have defective erythropoiesis, altered expression of autophagy genes, and a deficient response to vitamin D. Life sciences. 284:119900
- Chen, Z., Zhou, Z., Peng, X., Sun, C., Yang, D., Li, C., Zhu, R., Zhang, P., Zheng, L., Tang, C. (2021) Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart. The journal of physiological sciences : JPS. 71:33
- Han, S.L., Qian, Y.C., Limbu, S.M., Wang, J., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2021) Lipolysis and lipophagy play individual and interactive roles in regulating triacylglycerol and cholesterol homeostasis and mitochondrial form in zebrafish. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1866(9):158988
- Yatsuka, H., Hada, K., Shiraishi, H., Umeda, R., Morisaki, I., Urushibata, H., Shimizu, N., Sebastian, W.A., Hikida, T., Ishitani, T., Hanada, R., Shimada, T., Kimoto, K., Kubota, T., Hanada, T. (2020) Exosc2 deficiency leads to developmental disorders by causing a nucleotide pool imbalance in zebrafish. Biochemical and Biophysical Research Communications. 533:1470-1476
- Zhu, J., Tang, L., Qiao, S., Wang, L., Feng, Y., Wang, L., Wu, Q., Ding, P., Zhang, Z., Li, L. (2020) Low-dose methylmercury exposure impairs the locomotor activity of zebrafish: role of intestinal inositol metabolism. Environmental research. 190:110020
- Fan, X., Hou, T., Sun, T., Zhu, L., Zhang, S., Tang, K., Wang, Z. (2019) Starvation stress affects the maternal development and larval fitness in zebrafish (Danio rerio). The Science of the total environment. 695:133897
- Fan, X., Hou, T., Zhang, S., Guan, Y., Jia, J., Wang, Z. (2019) The cellular responses of autophagy, apoptosis, and 5-methylcytosine level in zebrafish cells upon nutrient deprivation stress. Chemosphere. 241:124989
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