Gene
mif
- ID
- ZDB-GENE-080708-1
- Name
- macrophage migration inhibitory factor
- Symbol
- mif Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity and phenylpyruvate tautomerase activity. Acts upstream of or within several processes, including auditory receptor cell development; camera-type eye development; and negative regulation of apoptotic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; immature eye; nervous system; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la019079Tg | Transgenic insertion | Unknown | Unknown | DNA |
1 - 1 of 1
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mif | Buono et al., 2021 | |
| CRISPR2-mif | Buono et al., 2021 | |
| MO1-mif | N/A | Ito et al., 2008 |
| MO2-mif | N/A | Ito et al., 2008 |
| MO3-mif | N/A | Ito et al., 2008 |
| MO4-mif | N/A | (3) |
| MO5-mif | N/A | Liu et al., 2013 |
| MO6-mif | N/A | Liu et al., 2013 |
1 - 8 of 8
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| juvenile rheumatoid arthritis | Alliance | {Rheumatoid arthritis, systemic juvenile, susceptibility to} | 604302 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor, conserved site | Tautomerase/MIF superfamily |
|---|---|---|---|---|---|
| UniProtKB:Q0ZBR7 | InterPro | 115 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-121D2 | ||
| Encodes | cDNA | MGC:198147 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198149 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001043321 (1) | 623 nt | ||
| Genomic | GenBank:CR855307 (1) | 167962 nt | ||
| Polypeptide | UniProtKB:Q0ZBR7 (1) | 115 aa |
- Jędrychowska, J., Vardanyan, V., Wieczor, M., Marciniak, A., Czub, J., Amini, R., Jain, R., Shen, H., Choi, H., Kuznicki, J., Korzh, V. (2024) Mutant analysis of Kcng4b reveals how the different functional states of the voltage-gated potassium channel regulate ear development. Developmental Biology. 513:50-62
- Ollewagen, T., Benecke, R.M., Smith, C. (2023) High species homology potentiates quantitative inflammation profiling in zebrafish using immunofluorescence. Heliyon. 10:e23635e23635
- Vaz-Rodrigues, R., Mazuecos, L., Villar, M., Contreras, M., Artigas-Jerónimo, S., González-García, A., Gortázar, C., de la Fuente, J. (2023) Multi-omics analysis of zebrafish response to tick saliva reveals biological processes associated with alpha-Gal syndrome. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 168:115829115829
- Wasilewska, I., Majewski, Ł., Adamek-Urbańska, D., Mondal, S.S., Baranykova, S., Gupta, R.K., Bielecki, D., Winata, C.L., Kuznicki, J. (2023) Lack of Stim2 Affects Vision-Dependent Behavior and Sensitivity to Hypoxia. Zebrafish. 20:146159146-159
- Buono, L., Corbacho, J., Naranjo, S., Almuedo-Castillo, M., Moreno-Marmol, T., de la Cerda, B., Sanbria-Reinoso, E., Polvillo, R., Díaz-Corrales, F.J., Bogdanovic, O., Bovolenta, P., Martínez-Morales, J.R. (2021) Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish. Nature communications. 12:3866
- Chiang, K.Y., Li, Y.W., Li, Y.H., Huang, S.J., Wu, C.L., Gong, H.Y., Wu, J.L. (2021) Progranulin A Promotes Compensatory Hepatocyte Proliferation via HGF/c-Met Signaling after Partial Hepatectomy in Zebrafish. International Journal of Molecular Sciences. 22(20):
- Cui, X., Du, C., Wan, S., Wu, D., Yan, L., Zhang, J., Li, J., Li, H., Yang, Z., Zhang, H., Zhang, J., Mu, H., Zhang, F., Peng, X., Liu, M., Hu, Y. (2021) Deficiency of Heat shock factor 4 promotes lens epithelial cell senescence through upregulating p21cip1 expression. Biochimica et biophysica acta. Molecular basis of disease. 1867(11):166233
- Ma, H., Liu, Z., Yang, Y., Feng, D., Dong, Y., Garbutt, T.A., Hu, Z., Wang, L., Luan, C., Cooper, C.D., Li, Y., Welch, J.D., Qian, L., Liu, J. (2021) Functional coordination of non-myocytes plays a key role in adult zebrafish heart regeneration. EMBO reports. 22(11):e52901
- Ayobahan, S.U., Eilebrecht, S., Baumann, L., Teigeler, M., Hollert, H., Kalkhof, S., Eilebrecht, E., Schäfers, C. (2020) Detection of biomarkers to differentiate endocrine disruption from hepatotoxicity in zebrafish (Danio rerio) using proteomics. Chemosphere. 240:124970
- Jedrychowska, J., Gasanov, E.V., Korzh, V. (2020) Kcnb1 plays a role in development of the inner ear. Developmental Biology. 471:65-75
1 - 10 of 31
Show