ZFIN Gene: prdm16

ZFIN ID: ZDB-GENE-080613-2

ZFIN ID: ZDB-GENE-080613-2

Gene Name:

PR domain containing 16

Gene Symbol:

prdm16 Nomenclature History

Previous Names:

fc09g08, wu:fc09g08 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 8 Mapping Details/Browsers

Description:

Predicted to have metal ion binding activity and nucleic acid binding activity. Involved in several processes, including cardiac muscle cell proliferation; embryonic cranial skeleton morphogenesis; and hematopoietic stem cell differentiation. Is expressed in several structures, including hindbrain neural rod; nervous system; pectoral fin bud; pronephric duct; and stomodeum. Orthologous to human PRDM16 (PR/SET domain 16).

Genome Resources:

Alliance (1), Gene:796720 (1),

GENE EXPRESSION
All Expression Data:	5 figures from 4 publications
Wild-type Stages, Structures:	Segmentation:5-9 somites (11.66h-14.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
	brain cranial ganglion diencephalon heart hindbrain hindbrain neural rod neurocranium olfactory placode pectoral fin pectoral fin bud peripheral olfactory organ pronephric duct stomodeum telencephalon whole organism
High Throughput Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la016416Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la016417Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la026615Tg	Transgenic Insertion	Unknown	Unknown	DNA
la026616Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la026617Tg	Transgenic Insertion	Unknown	Unknown	DNA
la029501Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
sa14438	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa14462	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa31682	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-prdm16	N/A	1
MO2-prdm16	N/A	3
MO3-prdm16	N/A	2
MO4-prdm16	N/A	1

PHENOTYPE

Data:	5 figures from 3 publications
Observed in:	cardiac muscle cell cell proliferation involved in heart morphogenesis ceratohyal cartilage ethmoid cartilage heart heart contraction hematopoietic stem cell differentiation Meckel's cartilage neurocranial trabecula neurocranium palatoquadrate cartilage ventral wall of dorsal aorta hematopoietic stem cell ventral wall of dorsal aorta

DISEASE ASSOCIATED WITH prdm16 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cardiomyopathy, dilated, 1LL	615373
		Left ventricular noncompaction 8	615373

DISEASE ASSOCIATED WITH prdm16 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	cardiac conduction (more)
Molecular Function	metal ion binding (more)

GO Terms (all 10)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	si:ch211-263k4.2-202 (1)	2783	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM prdm16 No data available

MARKER RELATIONSHIPS

prdm16 Contained in:	[BAC] DKEY-149F22 (order this)
prdm16 Encodes:	[EST] fc09g08

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_001922892 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:CR847782 (1)	81735 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A5XCD6 (1)	153 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 46)

ORTHOLOGY for prdm16 ( Chr: 8 )

CITATIONS (25)

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