Gene

prdm16

ID

ZDB-GENE-080613-2

Name

PR domain containing 16

Symbol

prdm16 Nomenclature History

Previous Names

fc09g08
si:ch211-263k4.2
wu:fc09g08 (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have metal ion binding activity and nucleic acid binding activity. Involved in several processes, including cardiac muscle cell proliferation; embryonic cranial skeleton morphogenesis; and hematopoietic stem cell differentiation. Is expressed in several structures, including hindbrain neural rod; nervous system; pectoral fin bud; pronephric duct; and stomodeum. Orthologous to human PRDM16 (PR/SET domain 16).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 13 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prdm16 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dilated cardiomyopathy 1LL	Alliance	Cardiomyopathy, dilated, 1LL	615373
dilated cardiomyopathy 1LL	Alliance	Left ventricular noncompaction 8	615373

Associated With prdm16 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001214	SET domain
Domain	IPR013087	Zinc finger C2H2-type
Domain	IPR044410	PRDM16, PR/SET domain
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily
Homologous_superfamily	IPR046341	SET domain superfamily

Domain Details Per Protein

Protein	Length	PRDM16, PR/SET domain	SET domain	SET domain superfamily	Zinc finger C2H2 superfamily	Zinc finger C2H2-type
UniProtKB:A0A8M2BEM7 InterPro	1302
UniProtKB:A0A8M9QJ45 InterPro	1180
UniProtKB:A0A8M3BC36 InterPro	1297
UniProtKB:A0A8M9Q420 InterPro	1332
UniProtKB:A0A8M9PRJ8 InterPro	1335
UniProtKB:A0A8M1QVB6 InterPro	1298
UniProtKB:A0A8M9QEA0 InterPro	1336
UniProtKB:A0A8M9QA80 InterPro	1238
UniProtKB:A0A8M2BES0 InterPro	1308

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	si:ch211-263k4.2-201 (1) Ensembl	Ensembl	2,727 nt	Select Tool ZFIN BLAST
mRNA	si:ch211-263k4.2-202 (1) Ensembl	Ensembl	2,783 nt	Select Tool
mRNA	si:ch211-263k4.2-203 (1) Ensembl	Ensembl	645 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations