Gene
prdm16
- ID
- ZDB-GENE-080613-2
- Name
- PR domain containing 16
- Symbol
- prdm16 Nomenclature History
- Previous Names
-
- fc09g08
- si:ch211-263k4.2
- wu:fc09g08 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable chromatin insulator sequence binding activity. Acts upstream of or within several processes, including Wnt signalosome assembly; cardiac muscle cell proliferation; and skeletal system development. Predicted to be active in chromosome. Is expressed in several structures, including head; hindbrain neural rod; nervous system; pectoral fin bud; and pronephric duct. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1LL. Orthologous to human PRDM16 (PR/SET domain 16).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| co1006 | Allele with one point mutation | Unknown | Unknown | CRISPR | |
| co1014 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| la016416Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la016417Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026615Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026616Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026617Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la029501Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa14438 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa14462 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-prdm16 | (2) | |
| MO1-prdm16 | N/A | Ding et al., 2013 |
| MO2-prdm16 | N/A | (3) |
| MO3-prdm16 | N/A | (2) |
| MO4-prdm16 | N/A | Arndt et al., 2013 |
| MO5-prdm16 | N/A | Matrone et al., 2021 |
| MO6-prdm16 | N/A | Matrone et al., 2021 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dilated cardiomyopathy 1LL | Alliance | Cardiomyopathy, dilated, 1LL | 615373 |
| dilated cardiomyopathy 1LL | Alliance | Left ventricular noncompaction 8 | 615373 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | PRDM16, PR/SET domain | SET domain | SET domain superfamily | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BEM7 | InterPro | 1302 | |||||
| UniProtKB:A0A8M9QJ45 | InterPro | 1180 | |||||
| UniProtKB:A0A8M3BC36 | InterPro | 1297 | |||||
| UniProtKB:A0A8M9Q420 | InterPro | 1332 | |||||
| UniProtKB:A0A8M9PRJ8 | InterPro | 1335 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:ch211-263k4.2-201
(1)
|
Ensembl | 2,727 nt | ||
| mRNA |
si:ch211-263k4.2-202
(1)
|
Ensembl | 2,783 nt | ||
| mRNA |
si:ch211-263k4.2-203
(1)
|
Ensembl | 645 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-386O14 | ZFIN Curated Data | |
| Contained in | BAC | CH211-263K4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-149F22 | ||
| Encodes | EST | fc09g08 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068223226 (1) | 10877 nt | ||
| Genomic | GenBank:CR381598 (1) | 146900 nt | ||
| Polypeptide | UniProtKB:A0A8M9QEA0 (1) | 1336 aa |
- Shull, L.C., Lencer, E.S., Kim, H.M., Goyama, S., Kurokawa, M., Costello, J.C., Jones, K., Artinger, K.B. (2022) PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation. Development (Cambridge, England). 149(4):
- Matrone, G., Xia, B., Chen, K., Denvir, M.A., Baker, A.H., Cooke, J.P. (2021) Fli1+ cells transcriptional analysis reveals an Lmo2-Prdm16 axis in angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 118(31):
- Shull, L.C., Sen, R., Menzel, J., Goyama, S., Kurokawa, M., Artinger, K.B. (2020) The conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development. Developmental Biology. 461(2):132-144
- Fellous, A., Earley, R.L., Silvestre, F. (2018) The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Gene. 687:173-187
- Han, T., Yang, C.S., Chang, K.Y., Zhang, D., Imam, F.B., Rana, T.M. (2016) Identification of novel genes and networks governing hematopoietic stem cell development. EMBO reports. 17(12):1814-1828
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Jungke, P., Hammer, J., Hans, S., Brand, M. (2015) Isolation of Novel CreERT2-Driver Lines in Zebrafish Using an Unbiased Gene Trap Approach. PLoS One. 10:e0129072
- Arndt, A.K., Schafer, S., Drenckhahn, J.D., Sabeh, M.K., Plovie, E.R., Caliebe, A., Klopocki, E., Musso, G., Werdich, A.A., Kalwa, H., Heinig, M., Padera, R.F., Wassilew, K., Bluhm, J., Harnack, C., Martitz, J., Barton, P.J., Greutmann, M., Berger, F., Hubner, N., Siebert, R., Kramer, H.H., Cook, S.A., MacRae, C.A., and Klaassen, S. (2013) Fine Mapping of the 1p36 Deletion Syndrome Identifies Mutation of PRDM16 as a Cause of Cardiomyopathy. American journal of human genetics. 93(1):67-77
- Ding, H.L., Clouthier, D.E., and Artinger, K.B. (2013) Redundant roles of PRDM family members in zebrafish craniofacial development. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(1):67-79
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
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