Gene
kmt2a
- ID
- ZDB-GENE-080521-3
- Name
- lysine (K)-specific methyltransferase 2A
- Symbol
- kmt2a Nomenclature History
- Previous Names
-
- mll
- im:7148357
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable histone H3K4 methyltransferase activity. Acts upstream of or within glial cell development; nucleate erythrocyte development; and paraxial mesoderm development. Predicted to be located in nucleus. Predicted to be part of histone methyltransferase complex. Is expressed in several structures, including blastoderm; blastodisc; intermediate cell mass of mesoderm; nervous system; and renal system. Human ortholog(s) of this gene implicated in acute myeloid leukemia; cervical cancer; myelofibrosis; and non-Hodgkin lymphoma. Orthologous to human KMT2A (lysine methyltransferase 2A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7148357 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb506 | Allele with one deletion | Exon 1 | Unknown | TALEN | |
| ihb507 | Allele with one deletion | Exon 5 | Unknown | CRISPR | |
| sa137 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa2815 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10905 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19111 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22638 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24984 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35881 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42541 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-kmt2a | (2) | |
| MO1-kmt2a | N/A | (2) |
| MO2-kmt2a | N/A | Wan et al., 2011 |
| MO3-kmt2a | N/A | (2) |
| MO4-kmt2a | N/A | Huang et al., 2013 |
| MO5-kmt2a | N/A | Huang et al., 2015 |
| TALEN1-kmt2a | Zebrafish Nomenclature Committee |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Wiedemann-Steiner syndrome | 605130 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Bromodomain | Bromodomain-like superfamily | Extended PHD (ePHD) domain | FY-rich, C-terminal | FY-rich, N-terminal | KMT2A, ePHD domain | KMT2A, PHD domain 1 | KMT2A, PHD domain 2 | KMT2A, PHD domain 3 | Methyltransferase, trithorax | Post-SET domain | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | SET domain | SET domain superfamily | Zinc finger, CXXC-type | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QL52
|
4219 | |||||||||||||||||||
|
UniProtKB:A8VKP8
|
4218 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-195H14 | ||
| Encodes | EST | IMAGE:7148357 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001110279 (1) | 12703 nt | ||
| Genomic | GenBank:CR847931 (1) | 134584 nt | ||
| Polypeptide | UniProtKB:F1QL52 (1) | 4219 aa |
- Shao, T., Ji, J.F., Zheng, J.Y., Li, C., Zhu, L.Y., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2022) Zbtb46 Controls Dendritic Cell Activation by Reprogramming Epigenetic Regulation of cd80/86 and cd40 Costimulatory Signals in a Zebrafish Model. Journal of immunology (Baltimore, Md. : 1950). 208(12):2686-2701
- Chen, X., Li, W. (2021) Isoflucypram cardiovascular toxicity in zebrafish (Danio rerio). The Science of the total environment. 787:147529
- Wang, D., Yang, L., Wang, J., Hu, G., Liu, Z., Yan, D., Serikuly, N., Alpyshov, E., Demin, K.A., Galstyan, D., Strekalova, T., de Abreu, M.S., Amstislavskaya, T.G., Kalueff, A.V. (2020) Behavioral and physiological effects of acute and chronic kava exposure in adult zebrafish. Neurotoxicology and teratology. 79:106881
- González-Rojo, S., Lombó, M., Fernández-Díez, C., Herráez, M.P. (2019) Male exposure to bisphenol a impairs spermatogenesis and triggers histone hyperacetylation in zebrafish testes. Environmental pollution (Barking, Essex : 1987). 248:368-379
- Ma, Z., Zhu, P., Shi, H., Guo, L., Zhang, Q., Chen, Y., Chen, S., Zhang, Z., Peng, J., Chen, J. (2019) PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components. Nature. 568(7751):259-263
- Liu, G., Wang, W., Hu, S., Wang, X., Zhang, Y. (2018) Inherited DNA methylation primes the establishment of accessible chromatin during genome activation. Genome research. 28(7):998-1007
- Tan, J., Zhao, L., Wang, G., Li, T., Li, D., Xu, Q., Chen, X., Shang, Z., Wang, J., Zhou, J. (2018) Human MLL-AF9 Overexpression Induces Aberrant Hematopoietic Expansion in Zebrafish. BioMed Research International. 2018:6705842
- Zhang, L., Yang, Y., Li, B., Scott, I.C., Lou, X. (2018) The DEAD box RNA helicase Ddx39ab is essential for myocyte and lens development in zebrafish. Development (Cambridge, England). 145(8)
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, Y.C., Shih, H.Y., Lin, S.J., Chiu, C.C., Ma, T.L., Yeh, T.H., Cheng, Y.C. (2015) The epigenetic factor Kmt2a/Mll1 regulates neural progenitor proliferation and neuronal and glial differentiation. Developmental Neurobiology. 75(5):452-62
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