Gene
myo9ab
- ID
- ZDB-GENE-080424-6
- Name
- myosin IXAb
- Symbol
- myo9ab Nomenclature History
- Previous Names
-
- myo9a2 (1)
- myo9al2
- im:7155152
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within axon extension; neuromuscular junction development, skeletal muscle fiber; and swimming behavior. Predicted to be located in several cellular components, including cytoplasm; growth cone; and synapse. Predicted to be active in actin filament and axonal growth cone. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome. Orthologous to human MYO9A (myosin IXA).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from O'Connor et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from O'Connor et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Myasthenic syndrome, congenital, 24, presynaptic | 618198 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Domain | IPR000159 | Ras-associating domain |
| Domain | IPR000198 | Rho GTPase-activating protein domain |
| Domain | IPR001609 | Myosin head, motor domain-like |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR036023 | Class IX myosin, motor domain |
| Family | IPR046987 | Unconventional class IX myosin |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | C1-like domain superfamily | Class IX myosin, motor domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin head, motor domain-like | P-loop containing nucleoside triphosphate hydrolase | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Ras-associating domain | Rho GTPase-activating protein domain | Rho GTPase activation protein | Ubiquitin-like domain superfamily | Unconventional class IX myosin |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB13ABJ7 | InterPro | 2304 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
myo9ab-201
(1)
|
Ensembl | 6,861 nt | ||
| mRNA |
myo9ab-203
(1)
|
Ensembl | 7,584 nt | ||
| ncRNA |
myo9ab-002
(1)
|
Ensembl | 497 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance