Gene
myo18ab
- ID
- ZDB-GENE-080423-1
- Name
- myosin XVIIIA b
- Symbol
- myo18ab Nomenclature History
- Previous Names
-
- myo18a (1)
- myo18l1
- si:ch211-103e6.2
- tiaf1
- wu:fb52c07
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Acts upstream of or within several processes, including Golgi organization; muscle tissue morphogenesis; and striated muscle cell development. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in head; notochord; skeletal muscle cell; and somite. Orthologous to human MYO18A (myosin XVIIIA).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa2798 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18136 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22645 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22646 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35889 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa42546 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42547 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42548 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sdu13 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-myo18ab | Zebrafish Nomenclature Committee | |
| MO1-myo18ab | N/A | (2) |
| TALEN1-myo18ab | Cao et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:A0AB32T1V1 | InterPro | 2674 |
| UniProtKB:A0AB32T1V4 | InterPro | 2673 |
| UniProtKB:A0AB32T1W8 | InterPro | 2539 |
| UniProtKB:A0AB32T343 | InterPro | 2629 |
| UniProtKB:A0AB32T3Q9 | InterPro | 2555 |
| UniProtKB:A0AB32T449 | InterPro | 2526 |
| UniProtKB:A0AB32T4J4 | InterPro | 2660 |
| UniProtKB:A0AB32T5K6 | InterPro | 2492 |
| UniProtKB:A0AB32T5Q9 | InterPro | 2491 |
| UniProtKB:A0AB32T703 | InterPro | 2476 |
| UniProtKB:A0AB32T7G9 | InterPro | 2658 |
| UniProtKB:A0AB32T8R8 | InterPro | 2688 |
| UniProtKB:A0AB32T8S5 | InterPro | 2174 |
| UniProtKB:A0AB32T8U1 | InterPro | 2689 |
| UniProtKB:A0AB32T8U7 | InterPro | 2684 |
| UniProtKB:A0AB32T8V4 | InterPro | 2252 |
| UniProtKB:A0AB32T8W1 | InterPro | 2159 |
| UniProtKB:A0AB32T968 | InterPro | 2514 |
| UniProtKB:A0AB32TAJ3 | InterPro | 2237 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
myo18ab-201
(1)
|
Ensembl | 7,674 nt | ||
| mRNA |
myo18ab-202
(1)
|
Ensembl | 9,522 nt | ||
| mRNA |
myo18ab-204
(1)
|
Ensembl | 7,530 nt | ||
| ncRNA |
myo18ab-002
(1)
|
Ensembl | 539 nt | ||
| ncRNA |
ottdart00000060038
(1)
|
Ensembl | 565 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-103E6 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-103P9 | ZFIN Curated Data | |
| Encodes | EST | fb52c07 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068213726 (1) | 11330 nt | ||
| Genomic | GenBank:CR394545 (2) | 177018 nt | ||
| Polypeptide | UniProtKB:A0AB32T8U1 (1) | 2689 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Cao, J.M., Cheng, X.N., Li, S.Q., Heller, S., Xu, Z.G., Shi, D.L. (2016) Identification of novel MYO18A interaction partners required for myoblast adhesion and muscle integrity. Scientific Reports. 6:36768
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Tsai, H.Y., Hamilton, A., Tinch, A.E., Guy, D.R., Gharbi, K., Stear, M.J., Matika, O., Bishop, S.C., Houston, R.D. (2015) Genome wide association and genomic prediction for growth traits in juvenile farmed Atlantic salmon using a high density SNP array. BMC Genomics. 16:969
- Cao, J., Li, S., Shao, M., Cheng, X., Xu, Z., Shi, D. (2014) The PDZ-Containing Unconventional Myosin XVIIIA Regulates Embryonic Muscle Integrity in Zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 41:417-428
- Sittaramane, V., and Chandrasekhar, A. (2008) Expression of unconventional myosin genes during neuronal development in zebrafish. Gene expression patterns : GEP. 8(3):161-170
- Woods, I.G., Kelly, P.D., Chu, F., Ngo-Hazelett, P., Yan, Y.-L., Huang, H., Postlethwait, J.H., and Talbot, W.S. (2000) A comparative map of the zebrafish genome. Genome research. 10(12):1903-1914
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