ep300a

ID

ZDB-GENE-080403-16

Name

EP300 lysine acetyltransferase a

Symbol

ep300a Nomenclature History

Previous Names

EP300b1 (1)
EP300b2 (1)
P300-A (1)
gb:dq017643
im:7158255

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable chromatin DNA binding activity; histone acetyltransferase activity; and transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of histone acetyltransferase complex and transcription regulator complex. Is expressed in blastoderm; blastomere; brain; digestive system; and heart. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; congestive heart failure; and idiopathic pulmonary fibrosis. Orthologous to human EP300 (EP300 lysine acetyltransferase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7158255 (1 image)
dq017643 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ep300a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
colorectal cancer	Alliance	Colorectal cancer, somatic	114500
Rubinstein-Taybi syndrome	Alliance	Rubinstein-Taybi syndrome 2	613684
		Menke-Hennekam syndrome 2	618333

Associated With ep300a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018359	Bromodomain, conserved site
Domain	IPR000197	Zinc finger, TAZ-type
Domain	IPR000433	Zinc finger, ZZ-type
Domain	IPR001487	Bromodomain
Domain	IPR003101	Coactivator CBP, KIX domain
Domain	IPR010303	CREB-binding protein/p300, atypical RING domain
Domain	IPR014744	Nuclear receptor coactivator, CREB-bp-like, interlocking
Domain	IPR031162	CBP/p300-type histone acetyltransferase domain
Domain	IPR056484	Histone acetyltransferase p300/CREBBP, PHD domain
Family	IPR013178	Histone acetyltransferase Rtt109/CBP
Homologous_superfamily	IPR009110	Nuclear receptor coactivator, interlocking
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR035898	TAZ domain superfamily
Homologous_superfamily	IPR036427	Bromodomain-like superfamily
Homologous_superfamily	IPR036529	Coactivator CBP, KIX domain superfamily
Homologous_superfamily	IPR037073	Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily
Homologous_superfamily	IPR038547	CBP/p300, atypical RING domain superfamily
Homologous_superfamily	IPR043145	Zinc finger, ZZ-type superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M3B7G7	InterPro	2673
UniProtKB:A0A8M3B4N4	InterPro	2672
UniProtKB:A0A8M3BE74	InterPro	2663
UniProtKB:A0A8M9PFF3	InterPro	2672
UniProtKB:A0A8M9QMW4	InterPro	2681
UniProtKB:A0A8M9PYD9	InterPro	2681
UniProtKB:A0A8M3AYE1	InterPro	2661
UniProtKB:A0A8M9PSB9	InterPro	2663
UniProtKB:A0A8M9PYE4	InterPro	2661
UniProtKB:A0A8M9PSB5	InterPro	2681
UniProtKB:A0A8M9PTF6	InterPro	1975
UniProtKB:A0A8M9Q4R2	InterPro	2673
UniProtKB:A0A8M9Q0N1	InterPro	1965
UniProtKB:A0A8M3BE71	InterPro	2682
UniProtKB:A0A8M3AYD6	InterPro	2680
UniProtKB:A0A8M9PFE9	InterPro	2682
UniProtKB:A0A8M9PAU5	InterPro	1956
UniProtKB:A0A8M9Q3W4	InterPro	1966
UniProtKB:A0A8M9Q9D0	InterPro	2680
UniProtKB:A0AB32TYF2	InterPro	2660
UniProtKB:A0AB32TYG8	InterPro	2681