ZFIN is now using GRCz12tu for Genomic Data
Gene
ep300a
- ID
- ZDB-GENE-080403-16
- Name
- EP300 lysine acetyltransferase a
- Symbol
- ep300a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables histone acetyltransferase activity. Acts upstream of or within embryonic cranial skeleton morphogenesis; heart looping; and pectoral fin development. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of histone acetyltransferase complex and transcription regulator complex. Is expressed in blastoderm; blastomere; brain; digestive system; and heart. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; congestive heart failure; and idiopathic pulmonary fibrosis. Orthologous to human EP300 (E1A binding protein p300).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017643 (7 images)
- IMAGE:7158255 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| Rubinstein-Taybi syndrome | Alliance | Rubinstein-Taybi syndrome 2 | 613684 |
| Menke-Hennekam syndrome 2 | 618333 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018359 | Bromodomain, conserved site |
| Domain | IPR000197 | Zinc finger, TAZ-type |
| Domain | IPR000433 | Zinc finger, ZZ-type |
| Domain | IPR001487 | Bromodomain |
| Domain | IPR003101 | Coactivator CBP, KIX domain |
| Domain | IPR010303 | CREB-binding protein/p300, atypical RING domain |
| Domain | IPR014744 | Nuclear receptor coactivator, CREB-bp-like, interlocking |
| Domain | IPR031162 | CBP/p300-type histone acetyltransferase domain |
| Domain | IPR056484 | Histone acetyltransferase p300/CREBBP, PHD domain |
| Family | IPR013178 | Histone acetyltransferase Rtt109/CBP |
| Homologous_superfamily | IPR009110 | Nuclear receptor coactivator, interlocking |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR035898 | TAZ domain superfamily |
| Homologous_superfamily | IPR036427 | Bromodomain-like superfamily |
| Homologous_superfamily | IPR036529 | Coactivator CBP, KIX domain superfamily |
| Homologous_superfamily | IPR038547 | CBP/p300, atypical RING domain superfamily |
| Homologous_superfamily | IPR043145 | Zinc finger, ZZ-type superfamily |
Domain Details Per Protein
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ep300a-201
(1)
|
Ensembl | 8,016 nt | ||
| mRNA |
ep300a-202
(1)
|
Ensembl | 10,239 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers