Gene
vdrb
- ID
- ZDB-GENE-080403-10
- Name
- vitamin D receptor b
- Symbol
- vdrb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Exhibits nuclear receptor activity. Contributes to DNA-binding transcription factor activity and vitamin D response element binding activity. Involved in embryonic heart tube morphogenesis and inner ear development. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including digestive system; heart; intestinal bulb primordium; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); lipid storage disease (multiple); melanoma (multiple); and tuberculosis (multiple). Orthologous to human VDR (vitamin D receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017633 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| vitamin D-dependent rickets type 2A | Alliance | Rickets, vitamin D-resistant, type IIA | 277440 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR042153 | VDR, DNA-binding domain |
| Family | IPR000324 | Vitamin D receptor |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR050234 | Nuclear hormone receptor family NR1 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR1 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | VDR, DNA-binding domain | Vitamin D receptor | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1L673
|
422 |
Interactions and Pathways
No data available
Plasmids
No data available