Gene

il2rga

ID

ZDB-GENE-080402-1

Name

interleukin 2 receptor, gamma a

Symbol

il2rga Nomenclature History

Previous Names

il2rgc.a (1)
si:dkey-18a10.4

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable cytokine binding activity and cytokine receptor activity. Acts upstream of or within lymphocyte differentiation. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including eye; heart; liver; pleuroperitoneal region; and thymus. Human ortholog(s) of this gene implicated in X-linked severe combined immunodeficiency; combined T cell and B cell immunodeficiency; and severe combined immunodeficiency. Orthologous to human IL2RG (interleukin 2 receptor subunit gamma).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With il2rga Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
X-linked severe combined immunodeficiency	Alliance	Severe combined immunodeficiency, X-linked	300400
		Combined immunodeficiency, X-linked, moderate	312863

Associated With il2rga Via Experimental Models

Human Disease	Fish	Conditions	Citations
severe combined immunodeficiency	il2rga^mdu2/mdu2	standard conditions	Sertori et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003531	Short hematopoietin receptor, family 1, conserved site
Domain	IPR003961	Fibronectin type III
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily