ZFIN is now using GRCz12tu for Genomic Data
Gene
elfn1b
- ID
- ZDB-GENE-080327-21
- Name
- extracellular leucine rich repeat and fibronectin type III domain containing 1b
- Symbol
- elfn1b Nomenclature History
- Previous Names
-
- elfn1 (1)
- sc:d0369
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to be located in membrane. Is expressed in brain and neurons. Used to study schizophrenia. Human ortholog(s) of this gene implicated in Dursun-Ozgul neurodevelopmental syndrome. Orthologous to human ELFN1 (extracellular leucine rich repeat and fibronectin type III domain containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d0369 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Dursun-Ozgul neurodevelopmental syndrome | Alliance | Dursun-Ozgul neurodevelopmental syndrome | 621344 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| schizophrenia | elfn1ba217/a217 | standard conditions | Thyme et al., 2019 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Domain | IPR055106 | ELFN1/ELFN2, fibronectin type-III domain |
| Family | IPR050541 | Leucine-rich repeat and transmembrane domain-containing protein |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cysteine-rich flanking region, C-terminal | ELFN1/ELFN2, fibronectin type-III domain | Leucine-rich repeat | Leucine-rich repeat and transmembrane domain-containing protein | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1Q7Y5 | InterPro | 814 | ||||||
| UniProtKB:A0AC58JG61 | InterPro | 814 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
elfn1b-201
(1)
|
Ensembl | 4,282 nt | ||
| mRNA |
elfn1b-202
(1)
|
Ensembl | 2,445 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers