Gene
elfn1b
- ID
- ZDB-GENE-080327-21
- Name
- extracellular leucine-rich repeat and fibronectin type III domain containing 1b
- Symbol
- elfn1b Nomenclature History
- Previous Names
-
- elfn1 (1)
- sc:d0369
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in brain and neurons. Used to study schizophrenia. Orthologous to human ELFN1 (extracellular leucine rich repeat and fibronectin type III domain containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d0369 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a217 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| sa78 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa89 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10220 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14916 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39553 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 6 of 6
Show
1 - 6 of 6
Show
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| schizophrenia | elfn1ba217/a217 | standard conditions | Thyme et al., 2019 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Domain | IPR055106 | ELFN1/ELFN2, fibronectin type-III domain |
| Family | IPR050541 | Leucine-rich repeat and transmembrane domain-containing protein |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Cysteine-rich flanking region, C-terminal | ELFN1/ELFN2, fibronectin type-III domain | Leucine-rich repeat | Leucine-rich repeat and transmembrane domain-containing protein | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1Q7Y5 | InterPro | 814 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
elfn1b-201
(1)
|
Ensembl | 4,282 nt | ||
| mRNA |
elfn1b-202
(1)
|
Ensembl | 2,445 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-65G16 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-232D5 | ZFIN Curated Data | |
| Encodes | EST | cssl:d0369 | Thisse et al., 2008 |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068221001 (1) | 7506 nt | ||
| Genomic | GenBank:CU104756 (1) | 161071 nt | ||
| Polypeptide | UniProtKB:F1Q7Y5 (1) | 814 aa |
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Charoensawan, V., Adryan, B., Martin, S., Söllner, C., Thisse, B., Thisse, C., Wright, G.J., and Teichmann, S.A. (2010) The Impact of Gene Expression Regulation on Evolution of Extracellular Signaling Pathways. Molecular & cellular proteomics : MCP. 9(12):2666-2677
- Söllner, C., and Wright, G.J. (2009) A cell surface interaction network of neural leucine-rich repeat receptors. Genome biology. 10(9):R99
1 - 6 of 6
Show