Gene
hspb6
- ID
- ZDB-GENE-080214-7
- Name
- heat shock protein, alpha-crystallin-related, b6
- Symbol
- hspb6 Nomenclature History
- Previous Names
-
- hspb13 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable unfolded protein binding activity. Predicted to be involved in negative regulation of apoptotic process; protein refolding; and response to heat. Predicted to be active in cytoplasm and nucleus. Is expressed in heart. Orthologous to human HSPB6 (heat shock protein family B (small) member 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha crystallin/Hsp20 domain | Alpha crystallin/Small heat shock protein, animal type | HSP20-like chaperone |
|---|---|---|---|---|---|
| UniProtKB:A6N6X0 | InterPro | 142 | |||
| UniProtKB:A0A8M1NE96 | InterPro | 142 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-51D2 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001100958 (1) | 2061 nt | ||
| Genomic | GenBank:CT027748 (1) | 166105 nt | ||
| Polypeptide | UniProtKB:A0A8M1NE96 (1) | 142 aa |
- Gou, D., Zhou, J., Song, Q., Wang, Z., Bai, X., Zhang, Y., Zuo, M., Wang, F., Chen, A., Yousaf, M., Yang, Z., Peng, H., Li, K., Xie, W., Tang, J., Yao, Y., Han, M., Ke, T., Chen, Q., Xu, C., Wang, Q. (2020) Mog1 knockout causes cardiac hypertrophy and heart failure by downregulating tbx5-cryab-hspb2 signaling in zebrafish. Acta physiologica (Oxford, England). 231(3):e13567
- Khamis, I., Chan, D.W., Shirriff, C.S., Campbell, J.H., Heikkila, J.J. (2016) Expression and localization of the Xenopus laevis small heat shock protein, HSPB6 (HSP20), in A6 kidney epithelial cells. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 201:12-21
- Huang, L., Zuo, Z., Zhang, Y., Wu, M., Lin, J.J., Wang, C. (2014) Use of toxicogenomics to predict the potential toxic effect of Benzo(a)pyrene on zebrafish embryos: Ocular developmental toxicity. Chemosphere. 108:55-61
- Marvin, M., O'Rourke, D., Kurihara, T., Juliano, C.E., Harrison, K.L., and Hutson, L.D. (2008) Developmental expression patterns of the zebrafish small heat shock proteins. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(2):454-463
- Elicker, K.S., and Hutson, L.D. (2007) Genome-wide analysis and expression profiling of the small heat shock proteins in zebrafish. Gene. 403(1-2):60-69
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