Gene
kiss1
- ID
- ZDB-GENE-080128-1
- Name
- KiSS-1 metastasis suppressor
- Symbol
- kiss1 Nomenclature History
- Previous Names
-
- kisspeptin (1)
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Enables kisspeptin receptor binding activity. Acts upstream of or within neuronal action potential and regulation of fear response. Is expressed in several structures, including brain; digestive system; fat cell; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 13 with or without anosmia. Orthologous to human KISS1 (KiSS-1 metastasis suppressor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 34 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Lupton et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa35074 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sq1sj | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sq2sj | Allele with one delins | Unknown | Premature Stop | CRISPR | |
| sq3sj | Allele with one insertion | Unknown | Premature Stop | CRISPR | |
| stl82 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tlv09 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| zf586 | Allele with one delins | Exon 1 | Unknown | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-kiss1 | (2) | |
| CRISPR2-kiss1 | (3) | |
| TALEN1-kiss1 | (3) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 13 with or without anosmia | Alliance | ?Hypogonadotropic hypogonadism 13 with or without anosmia | 614842 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR020207 | Metastasis-suppressor KiSS-1 |
Domain Details Per Protein
| Protein | Additional Resources | Length | Metastasis-suppressor KiSS-1 |
|---|---|---|---|
| UniProtKB:A8C5J1 | InterPro | 116 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-2.3kiss1:mCherry) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-235D17 | Biran et al., 2008 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001113489 (1) | 661 nt | ||
| Genomic | GenBank:BX571675 (1) | 207497 nt | ||
| Polypeptide | UniProtKB:A8C5J1 (1) | 116 aa |
- Powell, G.T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren, J., Lu, W., Young, R.M., Hawkins, T.A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D.W., Li, V.S.W., Wright, G.J., Jones, E.Y., Wilson, S.W. (2024) Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.). 384:573579573-579
- Wang, M., Luo, J., Dai, L., Feng, M., Cao, X., Zhang, J., Wan, Y., Yang, X., Wang, Y. (2024) Foxp2 deficiency impairs reproduction by modulating the hypothalamic-pituitary-gonadal axis in zebrafish. Biology of reproduction. 110(5):908-923
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Chen, X., Zheng, J., Zhang, J., Duan, M., Xu, H., Zhao, W., Yang, Y., Wang, C., Xu, Y. (2022) Exposure to difenoconazole induces reproductive toxicity in zebrafish by interfering with gamete maturation and reproductive behavior. The Science of the total environment. 838(Pt 1):155610
- Michel, L., Palma, K., Cerda, M., Lagadec, R., Mayeur, H., Fuentès, M., Besseau, L., Martin, P., Magnanou, E., Blader, P., Concha, M.L., Mazan, S. (2022) Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel. Frontiers in cell and developmental biology. 10:1015074
- Li, Y., Zhao, T., Liu, Y., Lin, H., Li, S., Zhang, Y. (2021) Knockout of tac3 Genes in Zebrafish Shows No Impairment of Reproduction. General and comparative endocrinology. 311:113839
- Roy, N., Ogawa, S., Maniam, R., Parhar, I. (2021) Habenula GPR139 is associated with fear learning in the zebrafish. Scientific Reports. 11:5549
- Abdul Satar, N.M., Ogawa, S., Parhar, I.S. (2020) Kisspeptin-1 regulates forebrain dopaminergic neurons in the zebrafish. Scientific Reports. 10:19361
- Atre, I., Mizrahi, N., Hausken, K., Yom-Din, S., Hurvitz, A., Degani, G., Levavi-Sivan, B. (2020) Molecular characterization of kisspeptin receptors and gene expression analysis during oogenesis in the russian sturgeon (Acipenser gueldenstaedtii). General and comparative endocrinology. 302:113691
- Chen, Q., Jingjing, A., Xie, D., Gong, S., Lian, X., Liu, Z., Shen, Y., Li, Y. (2020) Suppression and recovery of reproductive behavior induced by early life exposure to mercury in zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 239:108876
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