ZFIN ID: ZDB-GENE-080128-1
Gene Name: KiSS-1 metastasis suppressor
Gene Symbol: kiss1    Nomenclature History

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Previous Name: kisspeptin (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Exhibits G protein-coupled receptor binding activity. Involved in neuronal action potential and regulation of fear response. Predicted to localize to the neuron projection. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 13 with or without anosmia. Is expressed in several structures, including brain; fat cell; liver; male organism; and pleuroperitoneal region. Orthologous to human KISS1 (KiSS-1 metastasis suppressor).
Genome Resources: Alliance (1),  Gene:100134982 (1),  Ensembl(GRCz11):ENSDARG00000075829 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa35074 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sq1sj Small Deletion Unknown Unknown CRISPR
    sq2sj Indel Unknown Premature Stop CRISPR
    sq3sj Insertion Unknown Premature Stop CRISPR
    stl82 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf586 Indel Exon 1 Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-kiss1 1
    CRISPR2-kiss1 1
    TALEN1-kiss1 1
    DISEASE ASSOCIATED WITH kiss1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hypogonadotropic hypogonadism 13 with or without anosmia Alliance ?Hypogonadotropic hypogonadism 13 with or without anosmia 614842
    DISEASE ASSOCIATED WITH kiss1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process neuronal action potential (more)
    Cellular Component neuron projection (more)
    Molecular Function G protein-coupled receptor binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR020207 Metastasis-suppressor KiSS-1
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kiss1-201 (1)    Ensembl 659
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-kiss1 polyclonal Rabbit IHC 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kiss1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-2.3kiss1:mCherry) kiss1 mCherry Danio rerio 1 1
    MARKER RELATIONSHIPS
    kiss1 Contained in: [BAC] DKEY-235D17 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001113489 (1) 661 bp
    Genomic GenBank:BX571675 (1) 207497 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A8C5J1 (1) 116 aa
    Sequence Information (all 15)
    ORTHOLOGY for kiss1 ( Chr: 11 )
    CITATIONS (51)