ZFIN is now using GRCz12tu for Genomic Data
Gene
ptpn21
- ID
- ZDB-GENE-080102-4
- Name
- protein tyrosine phosphatase non-receptor type 21
- Symbol
- ptpn21 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within epithelial to mesenchymal transition; heart morphogenesis; and somitogenesis. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Is expressed in brain; pectoral fin; pericardial region; somite; and ventricular zone. Orthologous to human PTPN21 (protein tyrosine phosphatase non-receptor type 21).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Wyatt et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000299 | FERM domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Domain | IPR018979 | FERM, N-terminal |
| Domain | IPR018980 | FERM, C-terminal PH-like domain |
| Domain | IPR019748 | FERM central domain |
| Domain | IPR019749 | Band 4.1 domain |
| Domain | IPR041782 | PTPN14/21, FERM domain C-lobe |
| Family | IPR014392 | Protein-tyrosine phosphatase, non-receptor type-14/21 |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR014352 | FERM/acyl-CoA-binding protein superfamily |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
Domain Details Per Protein
| Protein | Additional Resources | Length | Band 4.1 domain | FERM/acyl-CoA-binding protein superfamily | FERM central domain | FERM, C-terminal PH-like domain | FERM domain | FERM, N-terminal | FERM superfamily, second domain | PH-like domain superfamily | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Protein-tyrosine phosphatase, non-receptor type-14/21 | PTPN14/21, FERM domain C-lobe | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1Q6T9 | InterPro | 1168 | ||||||||||||||||
| UniProtKB:A0A286YBL8 | InterPro | 1204 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptpn21-201
(1)
|
Ensembl | 7,797 nt | ||
| mRNA |
ptpn21-202
(1)
|
Ensembl | 3,733 nt | ||
| mRNA |
ptpn21-203
(1)
|
Ensembl | 3,625 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers