Gene

mst1ra

ID

ZDB-GENE-071218-2

Name

macrophage stimulating 1 receptor a

Symbol

mst1ra Nomenclature History

Previous Names

mst1r
RON (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including phagocytosis; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in gill and intestine. Human ortholog(s) of this gene implicated in nasopharynx carcinoma. Orthologous to human MST1R (macrophage stimulating 1 receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Huitema et al., 2012

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mst1ra Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Nasopharyngeal carcinoma, susceptibility to, 3}	617075

Associated With mst1ra Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR001627	Sema domain
Domain	IPR002909	IPT domain
Domain	IPR016201	PSI domain
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Family	IPR016244	Tyrosine-protein kinase, HGF/MSP receptor
Family	IPR031148	Plexin family
Family	IPR050122	Receptor Tyrosine Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR014756	Immunoglobulin E-set
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036352	Sema domain superfamily
Repeat	IPR002165	Plexin repeat

Domain Details Per Protein

Protein	Length	Immunoglobulin E-set	Immunoglobulin-like fold	IPT domain	Plexin family	Plexin repeat	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	PSI domain	Receptor Tyrosine Kinase	Sema domain	Sema domain superfamily	Serine-threonine/tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase, active site	Tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase, HGF/MSP receptor	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A8M3BAK5 InterPro	680
UniProtKB:E7EYX4 InterPro	1350
UniProtKB:A0A8M2BDJ7 InterPro	1356
UniProtKB:A0A8M3ATL8 InterPro	706

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	mst1ra-201 (1) Ensembl	Ensembl		4,722 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations