Gene
mst1ra
- ID
- ZDB-GENE-071218-2
- Name
- macrophage stimulating 1 receptor a
- Symbol
- mst1ra Nomenclature History
- Previous Names
-
- mst1r
- RON (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including cell migration; cell surface receptor protein tyrosine kinase signaling pathway; and phagocytosis. Predicted to act upstream of or within protein phosphorylation and semaphorin-plexin signaling pathway. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in gill and intestine. Human ortholog(s) of this gene implicated in nasopharynx carcinoma. Orthologous to human MST1R (macrophage stimulating 1 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Huitema et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa8795 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18851 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20791 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20792 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20793 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33939 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40770 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-mst1ra | N/A | (2) |
| MO2-mst1ra | N/A | Huitema et al., 2012 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Nasopharyngeal carcinoma, susceptibility to, 3} | 617075 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001627 | Sema domain |
| Domain | IPR002909 | IPT domain |
| Domain | IPR016201 | PSI domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Family | IPR016244 | Tyrosine-protein kinase, HGF/MSP receptor |
| Family | IPR050122 | Receptor Tyrosine Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036352 | Sema domain superfamily |
| Repeat | IPR002165 | Plexin repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | Plexin repeat | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | PSI domain | Receptor Tyrosine Kinase | Sema domain | Sema domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, HGF/MSP receptor | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3BAK5 | InterPro | 680 | ||||||||||||||||
| UniProtKB:E7EYX4 | InterPro | 1350 | ||||||||||||||||
| UniProtKB:A0A8M2BDJ7 | InterPro | 1356 | ||||||||||||||||
| UniProtKB:A0A8M3ATL8 | InterPro | 706 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mst1ra-201
(1)
|
Ensembl | 4,722 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-303F17 | ZFIN Curated Data | |
| Contained in | BAC | CH211-180C7 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005166118 (1) | 4976 nt | ||
| Genomic | GenBank:CR847900 (2) | 32365 nt | ||
| Polypeptide | UniProtKB:A0A8M2BDJ7 (1) | 1356 aa |
- Hatzold, J., Wessendorf, H., Pogoda, H.M., Bloch, W., Hammerschmidt, M. (2021) The Kunitz-type serine protease inhibitor Spint2 is required for cellular cohesion, coordinated cell migration and cell survival during zebrafish hatching gland development. Developmental Biology. 476:148-170
- Boswell, M., Boswell, W., Lu, Y., Savage, M., Walter, R.B. (2020) Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Scientific Reports. 10:3321
- He, Z., Crenshaw, E., Raper, J.A. (2019) Semaphorin/neuropilin binding specificities are stable over 400 million years of evolution. Biochemical and Biophysical Research Communications. 517(1):23-28
- Yang, F., Qiu, W., Li, R., Hu, J., Luo, S., Zhang, T., He, X., Zheng, C. (2018) Genome-wide identification of the interactions between key genes and pathways provide new insights into the toxicity of bisphenol F and S during early development in zebrafish. Chemosphere. 213:559-567
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huitema, L.F., Renn, J., Logister, I., Gray, J.K., Waltz, S.E., Flik, G., and Schulte-Merker, S. (2012) Macrophage-stimulating protein and calcium homeostasis in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(10):4092-4101
- Carney, T.J., von der Hardt, S., Sonntag, C., Amsterdam, A., Topczewski, J., Hopkins, N., and Hammerschmidt, M. (2007) Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis. Development (Cambridge, England). 134(19):3461-3471
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