flii

ID

ZDB-GENE-071212-3

Name

FLII actin remodeling protein

Symbol

flii Nomenclature History

Previous Names

im:7141769

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Acts upstream of or within sarcomere organization. Predicted to be located in centrosome and focal adhesion. Predicted to be active in actin cytoskeleton and nucleus. Is expressed in myotome. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human FLII (FLII actin remodeling protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7141769 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Naganawa et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With flii Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cardiomyopathy, dilated, 2J	620635

Associated With flii Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR007123	Gelsolin-like domain
Domain	IPR055414	Disease resistance R13L4/SHOC-2-like, LRR domain
Family	IPR007122	Villin/Gelsolin
Homologous_superfamily	IPR029006	ADF-H/Gelsolin-like domain superfamily
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Homologous_superfamily	IPR036180	Gelsolin-like domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype