Gene
srsf3b
- ID
- ZDB-GENE-071005-2
- Name
- serine and arginine rich splicing factor 3b
- Symbol
- srsf3b Nomenclature History
- Previous Names
-
- sfrs3b
- wu:fb44e08
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity. Orthologous to human SRSF3 (serine and arginine rich splicing factor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63887 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028466Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa13439 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24045 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain | Serine/Arginine-Rich Splicing Factor |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PV66
|
358 | ||||
|
UniProtKB:A5WWG4
|
164 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
srsf3b-201
(1)
|
Ensembl | 1,067 nt | ||
| mRNA |
srsf3b-203
(1)
|
Ensembl | 811 nt | ||
| mRNA |
srsf3b-204
(1)
|
Ensembl | 793 nt | ||
| mRNA |
srsf3b-205
(1)
|
Ensembl | 985 nt | ||
| mRNA |
srsf3b-207
(1)
|
Ensembl | 1,229 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-48M5 | ZFIN Curated Data | |
| Encodes | EST | fb44e08 | ||
| Encodes | cDNA | MGC:63887 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201323 (1) | 1277 nt | ||
| Genomic | GenBank:CU856139 (1) | 39899 nt | ||
| Polypeptide | UniProtKB:A0A8M9PV66 (1) | 358 aa |
- Joris, M., Schloesser, M., Baurain, D., Hanikenne, M., Muller, M., Motte, P. (2017) Number of inadvertent RNA targets for morpholino knockdown in Danio rerio is largely underestimated: evidence from the study of Ser/Arg-rich splicing factors. Nucleic acids research. 45:9547-9557
- Suarez-Bregua, P., Torres-Nuñez, E., Saxena, A., Guerreiro, P., Braasch, I., Prober, D.A., Moran, P., Cerda-Reverter, J.M., Du, S.J., Adrio, F., Power, D.M., Canario, A.V., Postlethwait, J.H., Bronner, M.E., Cañestro, C., Rotllant, J. (2017) Pth4, an ancient parathyroid hormone lost in eutherian mammals, reveals a new brain-to-bone signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31:569-583
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Haug, M.F., Gesemann, M., Lazovic, V., Neuhauss, S.C. (2015) Eumetazoan Cryptochrome Phylogeny and Evolution. Genome biology and evolution. 7(2):601-19
- Li, Z., Zheng, W., Li, H., Li, C., Gong, Z. (2015) Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes. PLoS One. 10:e0132319
- Liu, C., Hu, J., Qu, C., Wang, L., Huang, G., Niu, P., Zhong, Z., Hong, F., Wang, G., Postlethwait, J.H., Wang, H. (2015) Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes. Scientific Reports. 5:8113
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Ritter, D.I., Dong, Z., Guo, S., and Chuang, J.H. (2012) Transcriptional enhancers in protein-coding exons of vertebrate developmental genes. PLoS One. 7(5):e35202
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Song, H.D., Sun, X.J., Deng, M., Zhang, G.W., Zhou, Y., Wu, X.Y., Sheng, Y., Chen, Y., Ruan, Z., Jiang, C.L., Fan, H.Y., Zon, L.I., Kanki, J.P., Liu, T.X., Look, A.T., and Chen, Z. (2004) Hematopoietic gene expression profile in zebrafish kidney marrow. Proceedings of the National Academy of Sciences of the United States of America. 101(46):16240-16245
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