Gene
fars2
- ID
- ZDB-GENE-070928-38
- Name
- phenylalanyl-tRNA synthetase 2, mitochondrial
- Symbol
- fars2 Nomenclature History
- Previous Names
-
- zgc:173439
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable phenylalanine-tRNA ligase activity. Acts upstream of or within neuron projection morphogenesis; swimming behavior; and thigmotaxis. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 14 and hereditary spastic paraplegia 77. Orthologous to human FARS2 (phenylalanyl-tRNA synthetase 2, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| combined oxidative phosphorylation deficiency 14 | Alliance | Combined oxidative phosphorylation deficiency 14 | 614946 |
| hereditary spastic paraplegia 77 | Alliance | Spastic paraplegia 77, autosomal recessive | 617046 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002319 | Phenylalanyl-tRNA synthetase |
| Domain | IPR005121 | Ferrodoxin-fold anticodon-binding domain |
| Domain | IPR006195 | Aminoacyl-tRNA synthetase, class II |
| Family | IPR004530 | Phenylalanyl-tRNA synthetase, class IIc, mitochondrial |
| Homologous_superfamily | IPR036690 | Ferrodoxin-fold anticodon-binding domain superfamily |
| Homologous_superfamily | IPR045864 | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) |
Domain Details Per Protein
| Protein | Additional Resources | Length | Aminoacyl-tRNA synthetase, class II | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | Ferrodoxin-fold anticodon-binding domain | Ferrodoxin-fold anticodon-binding domain superfamily | Phenylalanyl-tRNA synthetase | Phenylalanyl-tRNA synthetase, class IIc, mitochondrial |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A8E4Z0 | InterPro | 449 |
Interactions and Pathways
No data available
Plasmids
No data available