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Gene

tjp2a

ID
ZDB-GENE-070925-2
Name
tight junction protein 2a (zona occludens 2)
Symbol
tjp2a Nomenclature History
Previous Names
  • tjp2.1 (1)
  • wu:fb10a11
  • zo-2.1 (1)
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in several processes, including establishment of endothelial intestinal barrier; positive regulation of blood-brain barrier permeability; and protein localization to cell-cell junction. Predicted to be located in membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in several structures, including digestive system; epidermis; nervous system; pronephros; and vasculature. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 51; disease of metabolism; and progressive familial intrahepatic cholestasis 4. Orthologous to human TJP2 (tight junction protein 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tjp2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
progressive familial intrahepatic cholestasis 4 Alliance Cholestasis, progressive familial intrahepatic 4 615878
Hypercholanemia, familial 1 607748
Associated With tjp2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001452 SH3 domain
Domain IPR001478 PDZ domain
Domain IPR008144 Guanylate kinase-like domain
Domain IPR008145 Guanylate kinase/L-type calcium channel beta subunit
Family IPR005417 Tight junction protein ZO
Family IPR005419 Tight junction protein ZO-2
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036034 PDZ superfamily
Domain Details Per Protein
Protein Length Guanylate kinase-like domain Guanylate kinase/L-type calcium channel beta subunit PDZ domain PDZ superfamily P-loop containing nucleoside triphosphate hydrolase SH3 domain SH3-like domain superfamily Tight junction protein ZO Tight junction protein ZO-2
UniProtKB:E7FBB9 1221
UniProtKB:F6PEN0 1198
UniProtKB:A0A2R8QB05 1225
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations