Gene
scn3b
- ID
- ZDB-GENE-070920-2
- Name
- sodium channel, voltage-gated, type III, beta
- Symbol
- scn3b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable sodium channel inhibitor activity. Predicted to be involved in regulation of heart rate by cardiac conduction and ventricular cardiac muscle cell action potential. Predicted to act upstream of or within regulation of monoatomic ion transmembrane transport and sodium ion transport. Predicted to be located in membrane. Predicted to be part of voltage-gated sodium channel complex. Is expressed in atrium; brain; cardiac ventricle; and eye. Human ortholog(s) of this gene implicated in Brugada syndrome 7. Orthologous to human SCN3B (sodium voltage-gated channel beta subunit 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Brugada syndrome 7 | Alliance | Atrial fibrillation, familial, 16 | 613120 |
Brugada syndrome 7 | Alliance | Brugada syndrome 7 | 613120 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR003599 | Immunoglobulin domain subtype |
Domain | IPR007110 | Immunoglobulin-like domain |
Domain | IPR013106 | Immunoglobulin V-set domain |
Family | IPR027098 | Sodium channel subunit beta-1/beta-3 |
Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
Protein | Length | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin V-set domain | Sodium channel subunit beta-1/beta-3 |
---|---|---|---|---|---|---|---|
UniProtKB:F8W4B3
|
241 | ||||||
UniProtKB:A0A8M3APT8
|
222 | ||||||
UniProtKB:Q06W27
|
220 |
Interactions and Pathways
No data available
Plasmids
No data available