ZFIN is now using GRCz12tu for Genomic Data
Gene
scn3b
- ID
- ZDB-GENE-070920-2
- Name
- sodium channel, voltage-gated, type III, beta
- Symbol
- scn3b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable sodium channel inhibitor activity and transmembrane transporter binding activity. Predicted to be involved in cardiac muscle cell action potential; regulation of heart rate by cardiac conduction; and sodium ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport and sodium ion transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Is expressed in atrium; brain; cardiac ventricle; and eye. Human ortholog(s) of this gene implicated in Brugada syndrome 7. Orthologous to human SCN3B (sodium voltage-gated channel beta subunit 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Brugada syndrome 7 | Alliance | Atrial fibrillation, familial, 16 | 613120 |
| Brugada syndrome 7 | Alliance | Brugada syndrome 7 | 613120 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013106 | Immunoglobulin V-set domain |
| Family | IPR027098 | Sodium channel subunit beta-1/beta-3 |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin V-set domain | Sodium channel subunit beta-1/beta-3 |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F8W4B3 | InterPro | 241 | ||||||
| UniProtKB:A0A8M3APT8 | InterPro | 222 | ||||||
| UniProtKB:Q06W27 | InterPro | 220 | ||||||
| UniProtKB:A0AB32T3B4 | InterPro | 202 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers