Gene
brinp2
- ID
- ZDB-GENE-070912-621
- Name
- bone morphogenetic protein/retinoic acid inducible neural-specific 2
- Symbol
- brinp2 Nomenclature History
- Previous Names
-
- fam5b
- si:dkey-9e8.1
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to be involved in cellular response to retinoic acid; central nervous system neuron differentiation; and negative regulation of mitotic cell cycle. Predicted to act upstream of or within positive regulation of neuron differentiation and regulation of cell cycle. Predicted to be active in cytoplasm; dendrite; and neuronal cell body. Is expressed in several structures, including fin bud; gill; head; heart; and muscle. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma. Orthologous to human BRINP2 (BMP/retinoic acid inducible neural specific 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Giousoh et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-brinp2 | Thyme et al., 2019 | |
| CRISPR2-brinp2 | Thyme et al., 2019 | |
| CRISPR3-brinp2 | Thyme et al., 2019 | |
| CRISPR4-brinp2 | Thyme et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BMP/retinoic acid-inducible neural-specific protein | Membrane attack complex component/perforin (MACPF) domain |
|---|---|---|---|---|
| UniProtKB:A0A0G2UMG0 | InterPro | 774 | ||
| UniProtKB:A0A8M1P6S6 | InterPro | 776 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
brinp2-201
(1)
|
Ensembl | 3,117 nt | ||
| mRNA |
brinp2-202
(1)
|
Ensembl | 2,325 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-9E8 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001309831 (1) | 9554 nt | ||
| Genomic | GenBank:BX537141 (2) | 264534 nt | ||
| Polypeptide | UniProtKB:A0A8M1P6S6 (1) | 776 aa |
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Giousoh, A., Vaz, R., Bryson-Richardson, R.J., Whisstock, J.C., Verkade, H., Bird, P.I. (2015) Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during Danio rerio development. Gene expression patterns : GEP. 18(1-2):37-43
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