ZFIN ID: ZDB-GENE-070912-553
Gene Name: zinc finger E-box binding homeobox 2a
Gene Symbol: zeb2a    Nomenclature History

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Previous Names: zeb2, sb:eu412, si:dkey-52o2.2, sip1a (1), Smad-interacting protein-1a (1), wu:fc92g08

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have metal ion binding activity and nucleic acid binding activity. Involved in several processes, including chordate embryonic development; convergent extension; and negative regulation of fibroblast growth factor receptor signaling pathway. Is expressed in several structures, including head; nervous system; neural plate; neuroectoderm; and tail bud. Human ortholog(s) of this gene implicated in Hirschsprung's disease and Mowat-Wilson syndrome. Orthologous to human ZEB2 (zinc finger E-box binding homeobox 2).
Genome Resources: Alliance (1),  Gene:100003889 (1),  Ensembl(GRCz11):ENSDARG00000062338 (1)
GENE EXPRESSION
All Expression Data: 9 figures from 4 publications
Directly Submitted Expression Data: 6 figures (26 images) from Thisse et al., 2005 [eu412]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 4 (96.0h-120.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010051Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la026845Tg Transgenic Insertion Unknown Unknown DNA
    la026846Tg Transgenic Insertion Unknown Unknown DNA
    la026847Tg Transgenic Insertion Unknown Unknown DNA
    la026848Tg Transgenic Insertion Unknown Unknown DNA
    sa16793 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34655 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34656 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-zeb2a N/A 1
    MO2-zeb2a N/A 1
    MO3-zeb2a N/A 1
    MO4-zeb2a N/A 1
    DISEASE ASSOCIATED WITH zeb2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Mowat-Wilson syndrome Alliance Mowat-Wilson syndrome 235730
    DISEASE ASSOCIATED WITH zeb2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process convergent extension involved in axis elongation (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA zeb2a-201 (1)    Ensembl 4058
    zeb2a-202 (1)    Ensembl 1351
    zeb2a-203 (1)    Ensembl 448
    zeb2a-204 (1)    Ensembl 859
    ncRNA zeb2a-004 (1)    Ensembl 940
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM zeb2a No data available
    MARKER RELATIONSHIPS
    zeb2a Contained in: [BAC] DKEY-28L22 (order this), DKEY-52O2 (1) (order this), DKEY-253G9 (order this)
    zeb2a Encodes: [EST] eu412 (1), fc92g08
    [cDNA] MGC:175265 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001135104 (1) 5277 nt
    Genomic RefSeq:NW_018394754 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:A0A286Y942 (1) 1242 aa
    Sequence Information (all 39)
    ORTHOLOGY for zeb2a ( Chr: 9 )
    CITATIONS (29)