ZFIN is now using GRCz12tu for Genomic Data
Gene
igf2bp2a
- ID
- ZDB-GENE-070912-44
- Name
- insulin-like growth factor 2 mRNA binding protein 2a
- Symbol
- igf2bp2a Nomenclature History
- Previous Names
-
- igf2bp2
- si:ch211-125m20.1
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in CRD-mediated mRNA stabilization and nervous system development. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IGF2BP2 (insulin like growth factor 2 mRNA binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from O'Hare et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Diabetes mellitus, noninsulin-dependent, susceptibility to} | 125853 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR004087 | K Homology domain |
| Domain | IPR004088 | K Homology domain, type 1 |
| Domain | IPR034843 | IGF2BP2, RNA recognition motif 1 |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
| Homologous_superfamily | IPR036612 | K Homology domain, type 1 superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | IGF2BP2, RNA recognition motif 1 | K Homology domain | K Homology domain, type 1 | K Homology domain, type 1 superfamily | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A9C3V8 | InterPro | 606 | |||||||
| UniProtKB:A0A0B4J1B0 | InterPro | 607 | |||||||
| UniProtKB:A0A2R8RHK1 | InterPro | 453 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
igf2bp2a-201
(1)
|
Ensembl | 2,707 nt | ||
| mRNA |
igf2bp2a-202
(1)
|
Ensembl | 2,405 nt | ||
| mRNA |
igf2bp2a-203
(1)
|
Ensembl | 1,827 nt | ||
| mRNA |
igf2bp2a-204
(1)
|
Ensembl | 1,912 nt | ||
| mRNA |
igf2bp2a-205
(1)
|
Ensembl | 2,101 nt | ||
| mRNA |
igf2bp2a-206
(1)
|
Ensembl | 1,608 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers