Gene

igf2bp2a

ID

ZDB-GENE-070912-44

Name

insulin-like growth factor 2 mRNA binding protein 2a

Symbol

igf2bp2a Nomenclature History

Previous Names

igf2bp2
si:ch211-125m20.1

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in CRD-mediated mRNA stabilization and nervous system development. Predicted to act upstream of or within mRNA transport and regulation of translation. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IGF2BP2 (insulin like growth factor 2 mRNA binding protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from O'Hare et al., 2016

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With igf2bp2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
type 2 diabetes mellitus	Alliance	{Diabetes mellitus, noninsulin-dependent, susceptibility to}	125853

Associated With igf2bp2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR004087	K Homology domain
Domain	IPR004088	K Homology domain, type 1
Domain	IPR034843	IGF2BP2, RNA recognition motif 1
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily
Homologous_superfamily	IPR036612	K Homology domain, type 1 superfamily

Domain Details Per Protein

Protein	Length	IGF2BP2, RNA recognition motif 1	K Homology domain	K Homology domain, type 1	K Homology domain, type 1 superfamily	Nucleotide-binding alpha-beta plait domain superfamily	RNA-binding domain superfamily	RNA recognition motif domain
UniProtKB:A9C3V8 InterPro	606
UniProtKB:A0A0B4J1B0 InterPro	607
UniProtKB:A0A2R8RHK1 InterPro	453

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	igf2bp2a-201 (1) Ensembl	Ensembl	2,707 nt	Select Tool ZFIN BLAST
mRNA	igf2bp2a-202 (1) Ensembl	Ensembl	2,405 nt	Select Tool ZFIN BLAST
mRNA	igf2bp2a-203 (1) Ensembl	Ensembl	1,827 nt	Select Tool ZFIN BLAST
mRNA	igf2bp2a-204 (1) Ensembl	Ensembl	1,912 nt	Select Tool ZFIN BLAST
mRNA	igf2bp2a-205 (1) Ensembl	Ensembl	2,101 nt	Select Tool ZFIN BLAST
mRNA	igf2bp2a-206 (1) Ensembl	Ensembl	1,608 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations