Gene
pip4k2ab
- ID
- ZDB-GENE-070912-272
- Name
- phosphatidylinositol-5-phosphate 4-kinase, type II, alpha b
- Symbol
- pip4k2ab Nomenclature History
- Previous Names
-
- si:ch211-279l9.5
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable 1-phosphatidylinositol-5-phosphate 4-kinase activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within phosphatidylinositol metabolic process and phosphorylation. Predicted to be located in lysosome; membrane; and nucleus. Predicted to be active in plasma membrane. Orthologous to human PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase type 2 alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Elouarrat et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002498 | Phosphatidylinositol-4-phosphate 4/5-kinase, core |
| Family | IPR023610 | Phosphatidylinositol-4/5-phosphate 5/4-kinase |
| Homologous_superfamily | IPR027483 | Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily |
| Homologous_superfamily | IPR027484 | Phosphatidylinositol-4-phosphate 5-kinase, N-terminal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Phosphatidylinositol-4/5-phosphate 5/4-kinase | Phosphatidylinositol-4-phosphate 4/5-kinase, core | Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily | Phosphatidylinositol-4-phosphate 5-kinase, N-terminal |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BAK4 | InterPro | 445 | ||||
| UniProtKB:B0UXW0 | InterPro | 413 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pip4k2ab-201
(1)
|
Ensembl | 1,011 nt | ||
| mRNA |
pip4k2ab-202
(1)
|
Ensembl | 532 nt | ||
| mRNA |
pip4k2ab-203
(1)
|
Ensembl | 2,253 nt | ||
| ncRNA |
pip4k2ab-002
(1)
|
Ensembl | 463 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-279L9 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005163367 (1) | 3767 nt | ||
| Genomic | GenBank:CR388093 (1) | 153673 nt | ||
| Polypeptide | UniProtKB:A0A8M2BAK4 (1) | 445 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Elouarrat, D., van der Velden, Y., Jones, D.R., Moolenaar, W.H., Divecha, N., and Haramis, A.P. (2013) Role of phosphatidylinositol 5-phosphate 4-kinase α in zebrafish development. The international journal of biochemistry & cell biology. 45(7):1293-301
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